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    Smug1 single-strand-selective monofunctional uracil-DNA glycosylase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Smug1provided by RGD
    Official Full Name
    single-strand-selective monofunctional uracil-DNA glycosylase 1provided by RGD
    Primary source
    RGD:631403
    See related
    EnsemblRapid:ENSRNOG00000036842 AllianceGenome:RGD:631403
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity and single-strand selective uracil DNA N-glycosylase activity. Involved in base-excision repair. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Orthologous to human SMUG1 (single-strand-selective monofunctional uracil-DNA glycosylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 39.7), Lung (RPKM 39.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Smug1 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (136166157..136177673, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (134288565..134302179, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144774155..144788333, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547478 Neighboring gene uncharacterized LOC120093746 Neighboring gene uncharacterized LOC103692988 Neighboring gene chromobox 5 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 Neighboring gene nuclear factor, erythroid 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian 5-formyluracil-DNA glycosylase. 1. Identification and characterization of a novel activity that releases 5-formyluracil from DNA. Matsubara M, et al. Biochemistry, 2003 May 6. PMID 12718542
    2. Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions. Masaoka A, et al. Biochemistry, 2003 May 6. PMID 12718543
    3. Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1. Boorstein RJ, et al. J Biol Chem, 2001 Nov 9. PMID 11526119
    4. hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup. Kavli B, et al. J Biol Chem, 2002 Oct 18. PMID 12161446
    5. Testicular protein Spag5 has similarity to mitotic spindle protein Deepest and binds outer dense fiber protein Odf1. Shao X, et al. Mol Reprod Dev, 2001 Aug. PMID 11468777

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This enzyme has a role in repair of 5-formyluracil and other oxidized and deaminated base lesions.
      Title: Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA N-glycosylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-strand selective uracil DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-strand selective uracil DNA N-glycosylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables uracil DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uracil DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uracil DNA N-glycosylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in base-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    single-strand selective monofunctional uracil-DNA glycosylase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177934.3 → NP_808795.1  single-strand selective monofunctional uracil-DNA glycosylase

      See identical proteins and their annotated locations for NP_808795.1

      Status: PROVISIONAL

      Source sequence(s)
      AY191521
      UniProtKB/Swiss-Prot
      Q811Q1
      UniProtKB/TrEMBL
      A6KCZ5
      Related
      ENSRNOP00000069685.1, ENSRNOT00000082149.3
      Conserved Domains (1) summary
      cd19374
      Location:29 → 258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      136166157..136177673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079348.2 → XP_038935276.1  single-strand selective monofunctional uracil-DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      Q811Q1
      UniProtKB/TrEMBL
      A6KCZ5
      Conserved Domains (1) summary
      cd19374
      Location:29 → 258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins

    2. XM_008765749.4 → XP_008763971.1  single-strand selective monofunctional uracil-DNA glycosylase isoform X1

      See identical proteins and their annotated locations for XP_008763971.1

      UniProtKB/Swiss-Prot
      Q811Q1
      UniProtKB/TrEMBL
      A6KCZ5
      Conserved Domains (1) summary
      cd19374
      Location:29 → 258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins

    3. XM_017594900.3 → XP_017450389.1  single-strand selective monofunctional uracil-DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      Q811Q1
      UniProtKB/TrEMBL
      A6KCZ5
      Conserved Domains (1) summary
      cd19374
      Location:29 → 258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q811Q1.1 GenPept UniProtKB/Swiss-Prot:Q811Q1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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