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    Gpr84 G protein-coupled receptor 84 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688730, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr84provided by RGD
    Official Full Name
    G protein-coupled receptor 84provided by RGD
    Primary source
    RGD:1585277
    See related
    EnsemblRapid:ENSRNOG00000036834 AllianceGenome:RGD:1585277
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human GPR84 (G protein-coupled receptor 84). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 13.2), Spleen (RPKM 3.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr84 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (136322374..136324648, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (134443904..134446173, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144934606..144937194, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene nuclear factor, erythroid 2 Neighboring gene COPI coat complex subunit zeta 1 Neighboring gene microRNA 148b Neighboring gene zinc finger protein 385A Neighboring gene uncharacterized LOC134479585 Neighboring gene integrin subunit alpha 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. Suzuki M, et al. J Biol Chem, 2013 Apr 12. PMID 23449982, Free PMC Article
    2. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor.
      Title: Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables urotensin II receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 84

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109509.1 → NP_001102979.1  G-protein coupled receptor 84

      See identical proteins and their annotated locations for NP_001102979.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474035
      UniProtKB/TrEMBL
      A6KD06, D4ACK0
      Related
      ENSRNOP00000052154.2, ENSRNOT00000055279.4
      Conserved Domains (1) summary
      cd15210
      Location:21 → 381
      7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      136322374..136324648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242449.5 → XP_006242511.1  G-protein coupled receptor 84 isoform X1

      See identical proteins and their annotated locations for XP_006242511.1

      UniProtKB/TrEMBL
      A6KD06, D4ACK0
      Conserved Domains (1) summary
      cd15210
      Location:21 → 381
      7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_006242448.4 → XP_006242510.1  G-protein coupled receptor 84 isoform X1

      See identical proteins and their annotated locations for XP_006242510.1

      UniProtKB/TrEMBL
      A6KD06, D4ACK0
      Conserved Domains (1) summary
      cd15210
      Location:21 → 381
      7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version

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