Ano7 anoctamin 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ano7provided by RGD
Full Name: anoctamin 7provided by RGD
Primary source: RGD:1302987
See related: EnsemblRapid:ENSRNOG00000023427 AllianceGenome:RGD:1302987
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ngep; Tmem16g
Summary: Predicted to enable intracellularly calcium-gated chloride channel activity and phospholipid scramblase activity. Predicted to be involved in calcium activated phospholipid scrambling and chloride transmembrane transport. Predicted to act upstream of or within calcium activated phospholipid scrambling and establishment of localization in cell. Predicted to be located in endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human ANO7 (anoctamin 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 22.4), Adrenal (RPKM 10.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q36

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (101364915..101392711)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (93917524..93945323)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (100511610..100551798)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF417869 (e-PCR)
- UniSTS:249699

RH131965 (e-PCR)
- UniSTS:215248

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables intracellularly calcium-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly calcium-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium activated galactosylceramide scrambling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium activated phosphatidylcholine scrambling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium activated phosphatidylserine scrambling	ISO Inferred from Sequence Orthology more info
involved_in calcium activated phospholipid scrambling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: anoctamin-7

Names: anoctamin-7-like; transmembrane protein 16G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004071.1 → NP_001004071.1 anoctamin-7

See identical proteins and their annotated locations for NP_001004071.1

Status: PROVISIONAL

Source sequence(s)

BK004074

UniProtKB/Swiss-Prot

Q6IFT6

Related

ENSRNOP00000033330.4, ENSRNOT00000033233.4

Conserved Domains (2) summary

pfam04547
Location:277 → 824

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:54 → 274

Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin