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    Poglut2 protein O-glucosyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316370, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Poglut2provided by RGD
    Official Full Name
    protein O-glucosyltransferase 2provided by RGD
    Primary source
    RGD:1304684
    See related
    EnsemblRapid:ENSRNOG00000011740 AllianceGenome:RGD:1304684
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kdelc1
    Summary
    Predicted to enable UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine. Predicted to be located in cytosol; endoplasmic reticulum lumen; and nucleoplasm. Predicted to be active in endomembrane system. Orthologous to human POGLUT2 (protein O-glucosyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 91.6), Adrenal (RPKM 77.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Poglut2 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (53748484..53801453, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (46256388..46268714, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (50872492..50884596, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 168 Neighboring gene testis expressed 30 Neighboring gene basic, immunoglobulin-like variable motif containing Neighboring gene ERCC excision repair 5, endonuclease Neighboring gene methyltransferase like 21C-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search. Kimata Y, et al. Gene, 2000 Dec 31. PMID 11167020
    2. Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling. Takeuchi H, et al. Proc Natl Acad Sci U S A, 2018 Sep 4. PMID 30127001, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189327

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables UDP-glucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-xylosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation via serine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein O-glucosyltransferase 2
    Names
    KDEL (Lys-Asp-Glu-Leu) containing 1
    KDEL motif containing 1
    KDEL motif-containing protein 1
    NP_001264157.1
    XP_063123236.1
    XP_063123237.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277228.1 → NP_001264157.1  protein O-glucosyltransferase 2 precursor

      See identical proteins and their annotated locations for NP_001264157.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AI78, A0A9K3Y6Q7, B5DFA5, F7FHZ5
      Related
      ENSRNOP00000016285.6, ENSRNOT00000016285.8
      Conserved Domains (3) summary
      smart00557
      Location:29 → 129
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:28 → 127
      Filamin; Filamin/ABP280 repeat
      pfam05686
      Location:151 → 484
      Glyco_transf_90; Glycosyl transferase family 90

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      53748484..53801453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267167.1 → XP_063123237.1  protein O-glucosyltransferase 2 isoform X1

    2. XM_063267166.1 → XP_063123236.1  protein O-glucosyltransferase 2 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108217.1: Suppressed sequence

      Description
      NM_001108217.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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