Brs3 bombesin receptor subtype 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Brs3provided by RGD
Official Full Name: bombesin receptor subtype 3provided by RGD
Primary source: RGD:628645
See related: EnsemblRapid:ENSRNOG00000000873 AllianceGenome:RGD:628645
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in neuronal cell body. Orthologous to human BRS3 (bombesin receptor subtype 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 9.9), Brain (RPKM 2.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: Xq36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (139944080..139969637)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (134906817..134932321)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (159484953..159510944)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRS-3 protein levels were decreased in diabetic rat and in obese and diabetic human fat pieces.
Title: Activation of bombesin receptor Subtype-3 by [D-Tyr(6),β-Ala(11),Phe(13),Nle(14)]bombesin(6-14) increased glucose uptake and lipogenesis in human and rat adipocytes.
This sstudy demonistrated comprehensive mapping of BRS-3 mRNA in the rat brain and double in situ hybridization was performed to determine whether BRS-3 colocalizes with other neurotransmitters or neuropeptides.
Title: Anatomical characterization of bombesin receptor subtype-3 mRNA expression in the rodent central nervous system.
bombesin receptor subtype-3 (BRS-3) was detected in the rat adult and fetal kidney.
Title: Developmental expression and biological activity of gastrin-releasing peptide and its receptors in the kidney.
Brs3 is expressed by the enteric nervous system and by interstitial cells of Cajal in the gastrointestinal tract.
Title: Bombesin receptor subtype-3 is expressed by the enteric nervous system and by interstitial cells of Cajal in the rat gastrointestinal tract.
results indicate that the sequence variation in the E3 loop is responsible for the species difference between rat and human BRS-3, and multiple residues in the E3 loop are involved in interactions with the agonist dY-bombesin
Title: Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3).

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bombesin receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in bombesin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bombesin receptor subtype-3

Names: BRS-3; bombesin-like receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433933.1 → NP_001420862.1 bombesin receptor subtype-3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8L2PYQ4
NM_152845.2 → NP_690058.1 bombesin receptor subtype-3 isoform 1

See identical proteins and their annotated locations for NP_690058.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q8K418

UniProtKB/TrEMBL

A6KSQ1

Conserved Domains (2) summary

pfam00001
Location:64 → 328

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:137 → 347

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

139944080..139969637

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257677.5 → XP_006257739.1 bombesin receptor subtype-3 isoform X1

Related

ENSRNOP00000001164.4, ENSRNOT00000001164.7

Conserved Domains (2) summary

pfam00001
Location:47 → 311

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:120 → 330

7tm_4; Olfactory receptor