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    Marf1 meiosis regulator and mRNA stability factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170946, updated on 9-Dec-2024

    Summary

    Symbol
    Marf1provided by RGD
    Full Name
    meiosis regulator and mRNA stability factor 1provided by RGD
    Primary source
    RGD:619770
    See related
    EnsemblRapid:ENSRNOG00000056248 AllianceGenome:RGD:619770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lkap
    Summary
    Predicted to enable CCR4-NOT complex binding activity. Predicted to be involved in female meiotic nuclear division; oogenesis; and regulation of gene expression. Predicted to act upstream of or within double-strand break repair. Predicted to be located in Golgi apparatus and peroxisome. Predicted to be active in cytoplasm. Orthologous to human MARF1 (meiosis regulator and mRNA stability factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 255.8), Spleen (RPKM 208.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Marf1 in Genome Data Viewer
    Location:
    10q11
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (1395271..1439974)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (888053..932760)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (908806..953481)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene nudE neurodevelopment protein 1 Neighboring gene microRNA 484 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1 Neighboring gene myocardin related transcription factor B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CCR4-NOT complex binding  
    enables RNA binding  
    enables RNA nuclease activity  
    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair  
    involved_in female meiotic nuclear division  
    involved_in female meiotic nuclear division  
    involved_in meiotic cell cycle  
    involved_in oogenesis  
    involved_in oogenesis  
    involved_in oogenesis  
    involved_in regulation of gene expression  
    involved_in regulation of gene expression  
    involved_in regulation of gene expression  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in cytoplasm  
    located_in intracellular membrane-bounded organelle  
    located_in peroxisome  
    located_in peroxisome  

    General protein information

    Preferred Names
    meiosis regulator and mRNA stability factor 1
    Names
    limkain-b1
    meiosis arrest female 1
    meiosis arrest female protein 1
    meiosis arrest female protein 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133421.3NP_596912.2  meiosis regulator and mRNA stability factor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      F1LNE9, Q8VIG2
      UniProtKB/TrEMBL
      A6KU39
      Related
      ENSRNOP00000073018.1, ENSRNOT00000091520.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      1395271..1439974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245854.5XP_006245916.1  meiosis regulator and mRNA stability factor 1 isoform X2

      UniProtKB/TrEMBL
      A6KU39
      Conserved Domains (10) summary
      cd09978
      Location:9871057
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:10831154
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:11591230
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:12431313
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:13951467
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:14701545
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:350492
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      cd12255
      Location:507579
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:770858
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
      cl14879
      Location:13191389
      LabA_like_C; C-terminal domain of LabA_like proteins
    2. XM_006245856.5XP_006245918.1  meiosis regulator and mRNA stability factor 1 isoform X4

      UniProtKB/TrEMBL
      A6KU39
      Conserved Domains (10) summary
      cd09978
      Location:822892
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:918989
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:9941065
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:10781148
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:12301302
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:13051380
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:171313
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      cd12255
      Location:328400
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:605693
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
      cl14879
      Location:11541224
      LabA_like_C; C-terminal domain of LabA_like proteins
    3. XM_063268363.1XP_063124433.1  meiosis regulator and mRNA stability factor 1 isoform X5

      UniProtKB/TrEMBL
      A6KU39
    4. XM_063268364.1XP_063124434.1  meiosis regulator and mRNA stability factor 1 isoform X6

    5. XM_063268362.1XP_063124432.1  meiosis regulator and mRNA stability factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0S5, A6KU39
    6. XM_003750779.6XP_003750827.1  meiosis regulator and mRNA stability factor 1 isoform X1

      See identical proteins and their annotated locations for XP_003750827.1

      UniProtKB/Swiss-Prot
      F1LNE9, Q8VIG2
      UniProtKB/TrEMBL
      A6KU39
      Conserved Domains (10) summary
      cd09978
      Location:10011071
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:10971168
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:11731244
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:12571327
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:14091481
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:14841559
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:350492
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      cd12255
      Location:507579
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:784872
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
      cl14879
      Location:13331403
      LabA_like_C; C-terminal domain of LabA_like proteins
    7. XM_006245855.5XP_006245917.1  meiosis regulator and mRNA stability factor 1 isoform X3

      See identical proteins and their annotated locations for XP_006245917.1

      UniProtKB/TrEMBL
      A0A0G2K0S5, A6KU39
      Related
      ENSRNOP00000071564.2, ENSRNOT00000077828.3
      Conserved Domains (10) summary
      cd09978
      Location:9551025
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:10511122
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:11271198
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:12111281
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:13631435
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:14381513
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:304446
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      cd12255
      Location:461533
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:738826
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
      cl14879
      Location:12871357
      LabA_like_C; C-terminal domain of LabA_like proteins
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