Arfip1 ARF interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arfip1provided by RGD
Official Full Name: ARF interacting protein 1provided by RGD
Primary source: RGD:708401
See related: EnsemblRapid:ENSRNOG00000010533 AllianceGenome:RGD:708401
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in intracellular protein transport; negative regulation of retrograde transport, endosome to Golgi; and regulation of Arp2/3 complex-mediated actin nucleation. Predicted to act upstream of or within regulation of protein secretion. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in trans-Golgi network membrane. Orthologous to human ARFIP1 (ADP ribosylation factor interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 148.5), Lung (RPKM 145.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (172141862..172224464, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (169843804..169924136, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (183503250..183582798, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The protein kinase D (PKD) phosphorylates Arfaptin-1 at serine 132, which disrupts the ability of Arfaptin-1 to inhibit the activity of ADP ribosylation factor, an important component of the vesicle scission machinery.
Title: The BAR domain protein Arfaptin-1 controls secretory granule biogenesis at the trans-Golgi network.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol-4-phosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arfaptin-1

Names: ADP-ribosylation factor interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021763.2 → NP_068531.1 arfaptin-1

See identical proteins and their annotated locations for NP_068531.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q9JHU5

UniProtKB/TrEMBL

A0A0G2JYA2, A6J5W8

Conserved Domains (2) summary

cd07660
Location:148 → 348

BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

pfam07490
Location:28 → 110

Tir_receptor_N; Translocated intimin receptor (Tir) N-terminus