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    Leprot leptin receptor overlapping transcript [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56766, updated on 9-Dec-2024

    Summary

    Official Symbol
    Leprotprovided by RGD
    Official Full Name
    leptin receptor overlapping transcriptprovided by RGD
    Primary source
    RGD:621034
    See related
    AllianceGenome:RGD:621034
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Obrgrp; Ob-Rgrp
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway; negative regulation of signal transduction; and regulation of protein localization. Predicted to be located in Golgi apparatus. Predicted to be active in endosome. Orthologous to human LEPROT (leptin receptor overlapping transcript). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 350.1), Lung (RPKM 286.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Leprot in Genome Data Viewer
    Location:
    5q33
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (121405170..121417273)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (116289843..116301951)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (120498910..120511011)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene uncharacterized LOC134479018 Neighboring gene uncharacterized LOC120102936 Neighboring gene leptin receptor Neighboring gene oogenesin 3, pseudogene 1 Neighboring gene PRAME family member 12, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor binding  
    enables signaling receptor binding  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi membrane  
    is_active_in endosome  
    located_in endosome  
    located_in endosome membrane  

    General protein information

    Preferred Names
    leptin receptor gene-related protein
    Names
    OB-R gene-related protein
    OB-receptor gene related protein (OB-RGRP)
    endospanin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020099.2NP_064484.1  leptin receptor gene-related protein

      See identical proteins and their annotated locations for NP_064484.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062003
      UniProtKB/Swiss-Prot
      Q9JLS8
      UniProtKB/TrEMBL
      A0A8I6B3V3, A6JRN9
      Conserved Domains (1) summary
      pfam04133
      Location:7124
      Vps55; Vacuolar protein sorting 55

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      121405170..121417273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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