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    Nr0b1 nuclear receptor subfamily 0, group B, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58850, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nr0b1provided by RGD
    Official Full Name
    nuclear receptor subfamily 0, group B, member 1provided by RGD
    Primary source
    RGD:62028
    See related
    EnsemblRapid:ENSRNOG00000003765 AllianceGenome:RGD:62028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ahch; DAX-1
    Summary
    Enables double-stranded DNA binding activity and sequence-specific DNA binding activity. Involved in several processes, including regulation of DNA-templated transcription; response to benzoic acid; and response to retinoic acid. Predicted to be located in several cellular components, including centriolar satellite; nuclear speck; and ribosome. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 2 and X-linked adrenal hypoplasia congenita. Orthologous to human NR0B1 (nuclear receptor subfamily 0 group B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 151.7) and Testes (RPKM 71.1) See more
    Orthologs
    NEW
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    Genomic context

    See Nr0b1 in Genome Data Viewer
    Location:
    Xq21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (54707658..54711786)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (50756886..50761014)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (54734385..54738513)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene actin, gamma 1 like 2 Neighboring gene spermatogenesis associated multipass transmembrane protein 3 Neighboring gene MAGE family member B2 Neighboring gene phosphoenolpyruvate carboxykinase 2 (mitochondrial), pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AF-2 domain binding  
    enables DNA binding PubMed 
    enables DNA hairpin binding  
    enables DNA hairpin binding  
    enables DNA hairpin binding  
    enables RNA binding  
    enables RNA binding  
    enables RNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables double-stranded DNA binding PubMed 
    enables nuclear receptor binding  
    enables nuclear receptor binding  
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables sequence-specific DNA binding PubMed 
    NOT enables sequence-specific DNA binding  
    enables transcription corepressor activity  
    enables transcription corepressor activity  
    enables transcription corepressor activity  
    Items 1 - 25 of 46
    Process Evidence Code Pubs
    involved_in Leydig cell differentiation  
    acts_upstream_of_or_within Leydig cell differentiation  
    involved_in Sertoli cell differentiation  
    acts_upstream_of_or_within Sertoli cell differentiation  
    involved_in adrenal gland development  
    involved_in adrenal gland development  
    acts_upstream_of_or_within adrenal gland development  
    involved_in adrenal gland development  
    involved_in adrenal gland development  
    involved_in endodermal cell differentiation  
    acts_upstream_of_or_within endodermal cell differentiation  
    involved_in gonad development  
    involved_in gonad development  
    involved_in male gonad development  
    acts_upstream_of_or_within male gonad development  
    involved_in male gonad development  
    involved_in male sex determination  
    acts_upstream_of_or_within male sex determination  
    involved_in negative regulation of DNA-binding transcription factor activity PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of intracellular steroid hormone receptor signaling pathway  
    involved_in negative regulation of intracellular steroid hormone receptor signaling pathway  
    involved_in negative regulation of steroid biosynthetic process  
    acts_upstream_of negative regulation of steroid biosynthetic process  
    acts_upstream_of negative regulation of steroid biosynthetic process  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in protein localization  
    involved_in protein localization  
    involved_in regulation of steroid biosynthetic process PubMed 
    involved_in response to benzoic acid PubMed 
    involved_in response to immobilization stress  
    acts_upstream_of_or_within response to immobilization stress  
    involved_in response to peptide hormone PubMed 
    involved_in response to retinoic acid PubMed 
    involved_in response to retinoic acid PubMed 
    acts_upstream_of_or_within sex determination  
    involved_in spermatogenesis  
    involved_in spermatogenesis  
    involved_in spermatogenesis PubMed 
    acts_upstream_of_or_within spermatogenesis  
    Items 1 - 25 of 46
    Component Evidence Code Pubs
    located_in centriolar satellite  
    located_in centriolar satellite  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in intracellular membrane-bounded organelle  
    located_in membrane  
    located_in membrane  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in ribosome  
    located_in ribosome  
    located_in ribosome  

    General protein information

    Preferred Names
    nuclear receptor subfamily 0 group B member 1
    Names
    adrenal hypoplasia, congenital homolog
    nuclear receptor DAX-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053317.2NP_445769.2  nuclear receptor subfamily 0 group B member 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      P70503, Q63152
      UniProtKB/TrEMBL
      A6IPW7, G3V6H3
      Related
      ENSRNOP00000005023.2, ENSRNOT00000005023.6
      Conserved Domains (2) summary
      cd07350
      Location:233466
      NR_LBD_Dax1; The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain
      pfam14046
      Location:147
      NR_Repeat; Nuclear receptor repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      54707658..54711786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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