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    Sell selectin L [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29259, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sellprovided by RGD
    Official Full Name
    selectin Lprovided by RGD
    Primary source
    RGD:3655
    See related
    EnsemblRapid:ENSRNOG00000002776 AllianceGenome:RGD:3655
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    A.11; LECAM-1; L-selectin
    Summary
    Enables glycolipid binding activity. Involved in several processes, including positive regulation of neutrophil chemotaxis; response to hyperoxia; and response to linoleic acid. Located in cell surface. Used to study colitis and peripheral vascular disease. Biomarker of abdominal aortic aneurysm; endometriosis; pancreatitis; and toxic shock syndrome. Human ortholog(s) of this gene implicated in Crohn's disease; IgA glomerulonephritis; and ulcerative colitis. Orthologous to human SELL (selectin L). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 587.9), Thymus (RPKM 264.3) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Sell in Genome Data Viewer
    Location:
    13q23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (78950100..78969604)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (76416969..76436444)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (82369820..82387774)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 8, pseudogene 1 Neighboring gene selectin E Neighboring gene selectin P Neighboring gene uncharacterized LOC134481524 Neighboring gene coagulation factor V

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Related articles in PubMed

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables carbohydrate binding  
    enables cell adhesion molecule binding  
    enables glycolipid binding PubMed 
    enables metal ion binding  
    enables oligosaccharide binding  
    enables oligosaccharide binding  
    enables oligosaccharide binding  
    enables oligosaccharide binding  
    enables protease binding  
    enables protease binding  
    enables sialic acid binding  
    Process Evidence Code Pubs
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
    involved_in cell adhesion  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  
    involved_in leukocyte tethering or rolling  
    involved_in leukocyte tethering or rolling  
    involved_in leukocyte tethering or rolling  
    involved_in leukocyte tethering or rolling  
    involved_in positive regulation of neutrophil chemotaxis PubMed 
    involved_in regulation of apoptotic process PubMed 
    acts_upstream_of_or_within response to ATP  
    involved_in response to cytokine  
    involved_in response to hyperoxia PubMed 
    involved_in response to linoleic acid PubMed 
    involved_in response to oleic acid PubMed 
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    located_in cell surface  
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane  
    is_active_in extracellular space  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    L-selectin
    Names
    CD62 antigen-like family member L
    LAM-1
    LECAM1
    leukocyte adhesion molecule 1
    leukocyte-endothelial cell adhesion molecule 1
    ly-22
    lymph node homing receptor
    lymphocyte antigen 22
    lymphocyte surface MEL-14 antigen
    selectin, lymphocyte

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019177.4NP_062050.3  L-selectin precursor

      See identical proteins and their annotated locations for NP_062050.3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P30836
      UniProtKB/TrEMBL
      Q63762
      Related
      ENSRNOP00000089128.2, ENSRNOT00000106952.2
      Conserved Domains (4) summary
      cd00033
      Location:197255
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03592
      Location:39157
      CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
      PHA02817
      Location:217326
      PHA02817; EEV Host range protein; Provisional
      cd00054
      Location:160192
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      78950100..78969604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090616.2XP_038946544.1  L-selectin isoform X1

      UniProtKB/TrEMBL
      F7EY63
      Related
      ENSRNOP00000112528.1, ENSRNOT00000153927.1
      Conserved Domains (4) summary
      cd00033
      Location:255313
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03592
      Location:97215
      CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
      PHA02817
      Location:275384
      PHA02817; EEV Host range protein; Provisional
      cd00054
      Location:218250
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
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