Git1 GIT ArfGAP 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Git1provided by RGD
Official Full Name: GIT ArfGAP 1provided by RGD
Primary source: RGD:69331
See related: EnsemblRapid:ENSRNOG00000061270 AllianceGenome:RGD:69331
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including GTPase activator activity; enzyme binding activity; and scaffold protein binding activity. A structural constituent of postsynaptic specialization. Involved in several processes, including cellular response to epidermal growth factor stimulus; neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of signal transduction. Acts upstream of or within dendritic spine development and immunological synapse formation. Located in several cellular components, including excitatory synapse; growth cone; and inhibitory synapse. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human GIT1 (GIT ArfGAP 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 490.5), Brain (RPKM 254.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (62840165..62854508)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (62342082..62356379)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (62656000..62664467, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:249809	BioGRID:114393	ARHGEF7	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:249809	BioGRID:248064	Akt3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:249809	BioGRID:247435	Camk2a	BioGRID	PubMed	Affinity Capture-MS
BioGRID:249809	BioGRID:260824	Eea1	BioGRID	PubMed	Co-fractionation
BioGRID:249809	BioGRID:249809	Git1	BioGRID	PubMed	Two-hybrid
BioGRID:249809	BioGRID:250505	Mapk1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:249809	BioGRID:111787	PXN	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:249809	BioGRID:263680	Snx6	BioGRID	PubMed	Co-fractionation
BioGRID:249809	BioGRID:112899	TGFB1I1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA
enables GTPase activator activity	IDA	PubMed
enables GTPase activator activity	IEA
enables gamma-tubulin binding	IEA
enables gamma-tubulin binding	ISO
enables gamma-tubulin binding	ISS
enables identical protein binding	IPI	PubMed
enables metal ion binding	IEA
enables protein binding	IPI	PubMed
enables protein phosphatase binding	IPI	PubMed
enables protein tyrosine kinase binding	IPI	PubMed
enables protein-containing complex binding	IEA
enables protein-containing complex binding	ISO
enables scaffold protein binding	IPI	PubMed
enables small GTPase binding	IBA
enables small GTPase binding	IDA	PubMed
enables structural constituent of postsynaptic specialization	IDA	PubMed
enables structural constituent of postsynaptic specialization	IMP	PubMed

Process	Evidence Code	Pubs
involved_in brain development	IBA
involved_in brain development	IEA
involved_in brain development	ISO
involved_in cell redox homeostasis	IEA
involved_in cell redox homeostasis	ISO
involved_in cell redox homeostasis	ISS
involved_in cellular response to epidermal growth factor stimulus	IDA	PubMed
involved_in cellular response to lipopolysaccharide	IEA
involved_in cellular response to lipopolysaccharide	ISO
involved_in cellular response to lipopolysaccharide	ISS
acts_upstream_of_or_within dendritic spine development	IGI	PubMed
involved_in ephrin receptor signaling pathway	IEA
acts_upstream_of_or_within ephrin receptor signaling pathway	ISO
acts_upstream_of_or_within immunological synapse formation	IGI	PubMed
involved_in intramembranous ossification	IEA
involved_in intramembranous ossification	ISO
involved_in intramembranous ossification	ISS
involved_in locomotory behavior	IEA
involved_in locomotory behavior	ISO
involved_in maintenance of postsynaptic specialization structure	IEA
involved_in motor learning	IEA
involved_in motor learning	ISO
involved_in negative regulation of ARF protein signal transduction	IDA	PubMed
involved_in negative regulation of glycolytic process	IEA
involved_in negative regulation of glycolytic process	ISO
involved_in negative regulation of glycolytic process	ISS
involved_in negative regulation of inflammatory response to wounding	IEA
involved_in negative regulation of inflammatory response to wounding	ISO
involved_in negative regulation of inflammatory response to wounding	ISS
involved_in negative regulation of interleukin-1 beta production	IEA
involved_in negative regulation of interleukin-1 beta production	ISO
involved_in negative regulation of interleukin-1 beta production	ISS
involved_in neuron development	IEA
involved_in neuron development	ISO
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP	PubMed
involved_in positive regulation of microtubule nucleation	IEA
involved_in positive regulation of microtubule nucleation	ISO
involved_in positive regulation of microtubule nucleation	ISS
involved_in positive regulation of receptor catabolic process	IMP	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IEA
involved_in presynaptic modulation of chemical synaptic transmission	ISO
involved_in regulation of ARF protein signal transduction	IBA
involved_in regulation of ARF protein signal transduction	IEA
involved_in regulation of G protein-coupled receptor signaling pathway	IBA
involved_in regulation of G protein-coupled receptor signaling pathway	IDA	PubMed
involved_in regulation of cytokinesis	IEA
involved_in regulation of cytokinesis	ISO
involved_in regulation of synaptic vesicle exocytosis	IEA
involved_in regulation of synaptic vesicle exocytosis	ISO
involved_in synaptic vesicle recycling	IBA

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA	PubMed
is_active_in GABA-ergic synapse	IMP	PubMed
located_in calyx of Held	IEA
is_active_in calyx of Held	ISO
located_in centrosome	IEA
located_in centrosome	ISO
located_in centrosome	ISS
is_active_in cytosol	IBA
located_in cytosol	IEA
located_in cytosol	ISO
located_in cytosol	TAS
located_in dendrite	IDA	PubMed
located_in endosome	IDA	PubMed
located_in excitatory synapse	IDA	PubMed
located_in focal adhesion	IEA
located_in focal adhesion	ISO
located_in focal adhesion	TAS	PubMed
is_active_in glutamatergic synapse	IDA	PubMed
located_in growth cone	IDA	PubMed
located_in inhibitory synapse	IDA	PubMed
located_in lamellipodium	IEA
located_in mitochondrion	IEA
located_in mitochondrion	ISO
located_in mitotic spindle pole	IEA
located_in mitotic spindle pole	ISO
located_in mitotic spindle pole	ISS
is_active_in neuron projection	IBA
is_active_in postsynapse	IBA
is_active_in postsynapse	IDA	PubMed
located_in postsynapse	IEA
located_in postsynapse	ISO
located_in postsynapse	ISS
located_in postsynaptic density	IEA
is_active_in presynapse	ISO
is_active_in synapse	IBA

General protein information

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Preferred Names: ARF GTPase-activating protein GIT1

Names: ARF GAP GIT1; CAT-1; CAT1; G protein-coupled receptor kinase interacting ArfGAP 1; G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein (GIT1); G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1; GRK-interactor 1; cool-associated and tyrosine-phosphorylated protein 1

NP_114002.1

EC 3.6.5.2

XP_038942874.1

EC 3.6.5.2

XP_038942875.1

EC 3.6.5.2

XP_063126041.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031814.2 → NP_114002.1 ARF GTPase-activating protein GIT1

See identical proteins and their annotated locations for NP_114002.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q9Z272

UniProtKB/TrEMBL

A0A8I6AGH2

Related

ENSRNOP00000073267.3, ENSRNOT00000078730.3

Conserved Domains (7) summary

smart00105
Location:3 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:123 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:337 → 365

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:649 → 763

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:418 → 482

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

62840165..62854508

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086946.2 → XP_038942874.1 ARF GTPase-activating protein GIT1 isoform X1

UniProtKB/TrEMBL

A0A8I6AGH2

Conserved Domains (6) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08846
Location:1 → 111

ArfGap_GIT1; GIT1 GTPase activating protein for Arf

pfam08518
Location:337 → 365

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:642 → 758

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:418 → 478

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_039086947.2 → XP_038942875.1 ARF GTPase-activating protein GIT1 isoform X2

UniProtKB/TrEMBL

A0A8I6AGH2

Related

ENSRNOP00000090288.2, ENSRNOT00000101598.2

Conserved Domains (6) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08846
Location:1 → 111

ArfGap_GIT1; GIT1 GTPase activating protein for Arf

pfam08518
Location:328 → 356

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:638 → 754

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:409 → 474

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_063269971.1 → XP_063126041.1 ARF GTPase-activating protein GIT1 isoform X3

UniProtKB/TrEMBL

A0A8I6AGH2

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	CH473948.1	EDM05285.1
		EDM05286.1
		EDM05287.1
genomic	JAXUCZ010000010.1 (62840165..62854508)	None	BN/NHsdMcwi
mRNA	AF085693.1	AAC83348.1