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    Hpx hemopexin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58917, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hpxprovided by RGD
    Official Full Name
    hemopexinprovided by RGD
    Primary source
    RGD:62040
    See related
    EnsemblRapid:ENSRNOG00000018257 AllianceGenome:RGD:62040
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hpxn
    Summary
    Predicted to enable heme transmembrane transporter activity and metal ion binding activity. Predicted to be involved in heme metabolic process. Predicted to act upstream of or within several processes, including positive regulation of immune effector process; positive regulation of type II interferon-mediated signaling pathway; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be active in extracellular space. Orthologous to human HPX (hemopexin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 20678.8) See more
    Orthologs
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    Genomic context

    See Hpx in Genome Data Viewer
    Location:
    1q32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (169344647..169352155, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (159932819..159940327, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (170423558..170431066, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sphingomyelin phosphodiesterase 1 Neighboring gene amyloid beta precursor protein binding family B member 1 Neighboring gene uncharacterized LOC134483766 Neighboring gene tripartite motif-containing 3 Neighboring gene ARF interacting protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heme transmembrane transporter activity  
    enables metal ion binding  
    Process Evidence Code Pubs
    involved_in heme metabolic process  
    acts_upstream_of_or_within heme metabolic process  
    involved_in heme transport  
    acts_upstream_of_or_within hemoglobin metabolic process  
    involved_in intracellular iron ion homeostasis  
    acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin  
    acts_upstream_of_or_within positive regulation of immunoglobulin production  
    acts_upstream_of_or_within positive regulation of response to type II interferon  
    acts_upstream_of_or_within positive regulation of type II interferon-mediated signaling pathway  
    acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein  
    acts_upstream_of_or_within regulation of protein metabolic process  
    acts_upstream_of type II interferon-mediated signaling pathway  
    acts_upstream_of tyrosine phosphorylation of STAT protein  
    Component Evidence Code Pubs
    is_active_in extracellular space  
    located_in extracellular space  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053318.1NP_445770.1  hemopexin precursor

      See identical proteins and their annotated locations for NP_445770.1

      Status: PROVISIONAL

      Source sequence(s)
      M62642
      UniProtKB/Swiss-Prot
      P20059, Q5BKB4
      UniProtKB/TrEMBL
      A6I7J2
      Related
      ENSRNOP00000024710.2, ENSRNOT00000024710.7
      Conserved Domains (1) summary
      cd00094
      Location:52230
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      169344647..169352155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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