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    Nup58 nucleoporin 58 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245922, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nup58provided by RGD
    Official Full Name
    nucleoporin 58provided by RGD
    Primary source
    RGD:631334
    See related
    EnsemblRapid:ENSRNOG00000012644 AllianceGenome:RGD:631334
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nup45; Nupl1; p58/p45
    Summary
    Enables identical protein binding activity and nuclear localization sequence binding activity. A structural constituent of nuclear pore. Involved in nucleocytoplasmic transport and regulation of protein import into nucleus. Located in nuclear envelope. Part of nuclear pore. Orthologous to human NUP58 (nucleoporin 58). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 123.7), Spleen (RPKM 106.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nup58 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (38534340..38583959, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (34358170..34407160, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (40496754..40545933, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 8A2 Neighboring gene ETS-related transcription factor Elf-2 pseudogene Neighboring gene uncharacterized LOC103693635 Neighboring gene myotubularin related protein 6 Neighboring gene APC membrane recruitment protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in nuclear envelope PubMed 
    located_in nuclear envelope  
    located_in nuclear membrane  
    part_of nuclear pore  
    part_of nuclear pore PubMed 
    part_of nuclear pore  
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    nucleoporin p58/p45
    Names
    58 kDa nucleoporin
    nucleoporin p45
    nucleoporin p58
    nucleoporin-like 1
    nucleoporin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139091.2NP_620791.1  nucleoporin p58/p45

      See identical proteins and their annotated locations for NP_620791.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085690
      UniProtKB/Swiss-Prot
      P70581, Q9JHE1, Q9QWK7, Q9Z2W7
      UniProtKB/TrEMBL
      A0A8I6G353, A6K694, A6K695
      Related
      ENSRNOP00000084647.1, ENSRNOT00000095956.2
      Conserved Domains (2) summary
      pfam10154
      Location:230408
      DUF2362; Uncharacterized conserved protein (DUF2362)
      pfam15967
      Location:32585
      Nucleoporin_FG2; Nucleoporin FG repeated region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      38534340..38583959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092982.2XP_038948910.1  nucleoporin p58/p45 isoform X3

      UniProtKB/TrEMBL
      A6K694
      Conserved Domains (1) summary
      pfam15967
      Location:2522
      Nucleoporin_FG2; Nucleoporin FG repeated region
    2. XM_006252093.5XP_006252155.1  nucleoporin p58/p45 isoform X2

      See identical proteins and their annotated locations for XP_006252155.1

      UniProtKB/TrEMBL
      A0A8L2Q9I5, A6K693, A6K694
      Related
      ENSRNOP00000017204.6, ENSRNOT00000017204.9
      Conserved Domains (1) summary
      pfam15967
      Location:32539
      Nucleoporin_FG2; Nucleoporin FG repeated region
    3. XM_039092981.2XP_038948909.1  nucleoporin p58/p45 isoform X1

      UniProtKB/TrEMBL
      A6K694
      Related
      ENSRNOP00000078538.1, ENSRNOT00000101273.2
      Conserved Domains (1) summary
      pfam15967
      Location:2568
      Nucleoporin_FG2; Nucleoporin FG repeated region
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