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    Tmem50b transmembrane protein 50B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360698, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmem50bprovided by RGD
    Official Full Name
    transmembrane protein 50Bprovided by RGD
    Primary source
    RGD:1307561
    See related
    EnsemblRapid:ENSRNOG00000002028 AllianceGenome:RGD:1307561
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307561
    Summary
    Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Predicted to be located in endoplasmic reticulum. Orthologous to human TMEM50B (transmembrane protein 50B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 297.6), Brain (RPKM 296.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tmem50b in Genome Data Viewer
    Location:
    11q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44290805..44323650, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (30804835..30837675, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (31719441..31752276, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS7-like Neighboring gene uncharacterized LOC134481058 Neighboring gene interferon gamma receptor 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene SON DNA and RNA binding protein Neighboring gene phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC109374

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in Golgi membrane  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025014.1 → NP_001020185.1  transmembrane protein 50B

      See identical proteins and their annotated locations for NP_001020185.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091349
      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
      Related
      ENSRNOP00000002775.5, ENSRNOT00000002775.7
      Conserved Domains (1) summary
      pfam05255
      Location:9 → 157
      UPF0220; Uncharacterized protein family (UPF0220)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      44290805..44323650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270610.1 → XP_063126680.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
    2. XM_017598025.3 → XP_017453514.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
      Conserved Domains (1) summary
      pfam05255
      Location:9 → 157
      UPF0220; Uncharacterized protein family (UPF0220)
    3. XM_006248066.5 → XP_006248128.1  transmembrane protein 50B isoform X1

      See identical proteins and their annotated locations for XP_006248128.1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
      Conserved Domains (1) summary
      pfam05255
      Location:9 → 157
      UPF0220; Uncharacterized protein family (UPF0220)
    4. XM_006248067.5 → XP_006248129.1  transmembrane protein 50B isoform X1

      See identical proteins and their annotated locations for XP_006248129.1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
      Conserved Domains (1) summary
      pfam05255
      Location:9 → 157
      UPF0220; Uncharacterized protein family (UPF0220)
    5. XM_063270609.1 → XP_063126679.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
    6. XM_006248068.5 → XP_006248130.1  transmembrane protein 50B isoform X1

      See identical proteins and their annotated locations for XP_006248130.1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
      Conserved Domains (1) summary
      pfam05255
      Location:9 → 157
      UPF0220; Uncharacterized protein family (UPF0220)
    7. XM_039088458.2 → XP_038944386.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
      Conserved Domains (1) summary
      pfam05255
      Location:9 → 157
      UPF0220; Uncharacterized protein family (UPF0220)
    8. XM_063270612.1 → XP_063126682.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
    9. XM_063270611.1 → XP_063126681.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
    10. XM_063270613.1 → XP_063126683.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
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