U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298696, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pin1provided by RGD
    Official Full Name
    peptidylprolyl cis/trans isomerase, NIMA-interacting 1provided by RGD
    Primary source
    RGD:1310299
    See related
    EnsemblRapid:ENSRNOG00000085482 AllianceGenome:RGD:1310299
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including GTPase activating protein binding activity; beta-catenin binding activity; and protein phosphorylated amino acid binding activity. Involved in positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of protein phosphorylation; and regulation of neuron apoptotic process. Predicted to be located in several cellular components, including ciliary basal body; midbody; and nucleoplasm. Predicted to be active in glutamatergic synapse; nucleus; and postsynaptic cytosol. Used to study asthma and secondary hyperparathyroidism. Orthologous to human PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 307.0), Heart (RPKM 253.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pin1 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (27465538..27477016)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19189408..19200785)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (21669236..21680615)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480143 Neighboring gene F-box and leucine-rich repeat protein 12 Neighboring gene ubiquitin-like 5 Neighboring gene olfactomedin 2 Neighboring gene collagen type V alpha 3 chain

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activating protein binding  
    enables beta-catenin binding  
    enables cis-trans isomerase activity  
    enables cytoskeletal motor activity  
    enables mitogen-activated protein kinase kinase binding  
    enables peptidyl-prolyl cis-trans isomerase activity  
    enables peptidyl-prolyl cis-trans isomerase activity  
    enables phosphoprotein binding  
    enables phosphoserine residue binding  
    enables phosphothreonine residue binding  
    enables protein binding PubMed 
    enables ubiquitin ligase activator activity  
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia  
    NOT involved_in microtubule polymerization  
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of SMAD protein signal transduction  
    involved_in negative regulation of amyloid-beta formation  
    involved_in negative regulation of cell motility  
    involved_in negative regulation of neuron apoptotic process PubMed 
    involved_in negative regulation of protein catabolic process  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
    involved_in neuron differentiation  
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of cell growth involved in cardiac muscle cell development PubMed 
    involved_in positive regulation of neuron apoptotic process PubMed 
    involved_in positive regulation of protein phosphorylation PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein peptidyl-prolyl isomerization  
    involved_in protein stabilization  
    involved_in protein targeting to mitochondrion  
    acts_upstream_of_or_within regulation of cell population proliferation  
    acts_upstream_of_or_within regulation of cytokinesis  
    involved_in regulation of gene expression  
    involved_in regulation of protein localization to nucleus  
    involved_in regulation of protein phosphorylation  
    involved_in regulation of protein stability  
    involved_in regulation protein catabolic process at postsynapse  
    involved_in response to hypoxia  
    involved_in synapse organization  
    Items 1 - 25 of 29
    Component Evidence Code Pubs
    located_in ciliary basal body  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    is_active_in glutamatergic synapse  
    located_in midbody  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    is_active_in postsynaptic cytosol  

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
    Names
    protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
    NP_001100171.1
    XP_063121107.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106701.2NP_001100171.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

      See identical proteins and their annotated locations for NP_001100171.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158867
      UniProtKB/TrEMBL
      B0BNL2, F7EW79
      Related
      ENSRNOP00000098917.1, ENSRNOT00000135076.1
      Conserved Domains (2) summary
      pfam00397
      Location:737
      WW; WW domain
      cl29122
      Location:53164
      Rotamase_2; PPIC-type PPIASE domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      27465538..27477016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265037.1XP_063121107.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X1

    External link. Please review our privacy policy.