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    Erlin1 ER lipid raft associated 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293939, updated on 9-Dec-2024

    Summary

    Official Symbol
    Erlin1provided by RGD
    Official Full Name
    ER lipid raft associated 1provided by RGD
    Primary source
    RGD:1307058
    See related
    EnsemblRapid:ENSRNOG00000012911 AllianceGenome:RGD:1307058
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spfh1; RGD1307058
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be involved in ERAD pathway; SREBP signaling pathway; and negative regulation of lipid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 62. Orthologous to human ERLIN1 (ER lipid raft associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 182.4), Kidney (RPKM 139.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Erlin1 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (252870356..252905681, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (242921147..242956472, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (263810439..263845762, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene carboxypeptidase N subunit 1 Neighboring gene casein kinase 2 alpha 1, pseudogene 2 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 23 Neighboring gene component of inhibitor of nuclear factor kappa B kinase complex Neighboring gene CWF19 like cell cycle control factor 1 Neighboring gene small nucleolar RNA, H/ACA box 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding  
    enables cholesterol binding  
    enables ubiquitin protein ligase binding  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    erlin-1
    Names
    SPFH domain family, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106353.1NP_001099823.1  erlin-1

      See identical proteins and their annotated locations for NP_001099823.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473986
      UniProtKB/TrEMBL
      A0A8I6B6J2, B1WBY7, F7ERV0
      Related
      ENSRNOP00000017268.6, ENSRNOT00000017268.7
      Conserved Domains (1) summary
      cd03406
      Location:18310
      SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      252870356..252905681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231441.5XP_006231503.1  erlin-1 isoform X1

      See identical proteins and their annotated locations for XP_006231503.1

      UniProtKB/TrEMBL
      A0A8I6B6J2, B1WBY7, F7ERV0
      Related
      ENSRNOP00000097939.1, ENSRNOT00000103941.2
      Conserved Domains (1) summary
      cd03406
      Location:18310
      SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
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