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    Dtx1 deltex E3 ubiquitin ligase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687424, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dtx1provided by RGD
    Official Full Name
    deltex E3 ubiquitin ligase 1provided by RGD
    Primary source
    RGD:1585380
    See related
    EnsemblRapid:ENSRNOG00000050848 AllianceGenome:RGD:1585380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Notch binding activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including Notch signaling pathway; negative regulation of neuron differentiation; and regulation of Notch signaling pathway. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; glial cell differentiation; and negative regulation of T cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleoplasm. Orthologous to human DTX1 (deltex E3 ubiquitin ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 42.7), Brain (RPKM 39.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dtx1 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41510252..41541433)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35849647..35880835)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41383885..41415783)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 2'-5'-oligoadenylate synthetase 3 Neighboring gene 2'-5' oligoadenylate synthetase 2 Neighboring gene RAS protein activator like 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. Chastagner P, et al. EMBO Rep, 2006 Nov. PMID 17028573, Free PMC Article
    2. Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development. Yun TJ, et al. J Immunol, 2003 Jun 15. PMID 12794108
    3. Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. Yamamoto N, et al. J Biol Chem, 2001 Nov 30. PMID 11564735
    4. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Kishi N, et al. Int J Dev Neurosci, 2001 Feb. PMID 11226752
    5. DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Eiraku M, et al. Nat Neurosci, 2005 Jul. PMID 15965470

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase DTX1
    Names
    deltex 1, E3 ubiquitin ligase
    deltex homolog 1
    NP_001414550.1
    XP_006249474.1
    XP_038945812.1
    XP_063127729.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427621.1 → NP_001414550.1  E3 ubiquitin-protein ligase DTX1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J1I1, M0RA58

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      41510252..41541433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089884.2 → XP_038945812.1  E3 ubiquitin-protein ligase DTX1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4D7, A6J1I1
      Conserved Domains (3) summary
      smart00678
      Location:26 → 102
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16671
      Location:415 → 487
      RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
      pfam18102
      Location:490 → 624
      DTC; Deltex C-terminal domain

    2. XM_006249412.5 → XP_006249474.1  E3 ubiquitin-protein ligase DTX1 isoform X1

      See identical proteins and their annotated locations for XP_006249474.1

      UniProtKB/TrEMBL
      A0A8I6A4D7, A6J1I1
      Related
      ENSRNOP00000066399.2, ENSRNOT00000074974.3
      Conserved Domains (3) summary
      smart00678
      Location:26 → 102
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16671
      Location:415 → 487
      RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
      pfam18102
      Location:490 → 624
      DTC; Deltex C-terminal domain

    3. XM_063271659.1 → XP_063127729.1  E3 ubiquitin-protein ligase DTX1 isoform X2

      UniProtKB/TrEMBL
      A6J1I1, M0RA58
    Nucleotide Protein Strain
    Heading Accession and Version

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