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    Cox20 cytochrome c oxidase assembly factor COX20 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289278, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cox20provided by RGD
    Official Full Name
    cytochrome c oxidase assembly factor COX20provided by RGD
    Primary source
    RGD:1309105
    See related
    EnsemblRapid:ENSRNOG00000076247 AllianceGenome:RGD:1309105
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam36a; RGD1309105
    Summary
    Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 11. Orthologous to human COX20 (cytochrome c oxidase assembly factor COX20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 500.8), Thymus (RPKM 406.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cox20 in Genome Data Viewer
    Location:
    13q25
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (92592260..92604129)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (90065900..90075386)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (96219853..96224023)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene chromosome 13 C1orf202 homolog Neighboring gene basic transcription factor 3, pseudogene 1 Neighboring gene heterogeneous nuclear ribonucleoprotein U Neighboring gene 60S ribosomal protein L17 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia. Szklarczyk R, et al. Hum Mol Genet, 2013 Feb 15. PMID 23125284
    2. Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase. Bourens M, et al. Hum Mol Genet, 2014 Jun 1. PMID 24403053, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase assembly factor COX20
    Names
    COX20 Cox2 chaperone homolog
    COX20 cytochrome C oxidase assembly factor
    family with sequence similarity 36, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105976.1 → NP_001099446.1  cytochrome c oxidase assembly factor COX20

      See identical proteins and their annotated locations for NP_001099446.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473985
      UniProtKB/TrEMBL
      A0A8I5ZSY5, A6JGE3
      Related
      ENSRNOP00000100989.1, ENSRNOT00000159881.1
      Conserved Domains (1) summary
      pfam12597
      Location:13 → 97
      DUF3767; Protein of unknown function (DUF3767)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      92592260..92604129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090533.2 → XP_038946461.1  cytochrome c oxidase assembly factor COX20 isoform X1

      Conserved Domains (1) summary
      pfam12597
      Location:13 → 76
      DUF3767; Protein of unknown function (DUF3767)
    Nucleotide Protein Strain
    Heading Accession and Version

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