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    Zc3h10 zinc finger CCCH type containing 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685928, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zc3h10provided by RGD
    Official Full Name
    zinc finger CCCH type containing 10provided by RGD
    Primary source
    RGD:1587846
    See related
    EnsemblRapid:ENSRNOG00000040281 AllianceGenome:RGD:1587846
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable miRNA binding activity. Predicted to be involved in negative regulation of miRNA processing and regulation of RNA splicing. Predicted to act upstream of with a positive effect on post-transcriptional regulation of gene expression. Predicted to be located in nucleus. Orthologous to human ZC3H10 (zinc finger CCCH-type containing 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 46.7), Thymus (RPKM 41.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zc3h10 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1557948..1562129, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (973415..977742, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2968428..2972521, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene extended synaptotagmin 1 Neighboring gene ribosomal protein S23, pseudogene 3 Neighboring gene ribosomal protein S15, pseudogene 2 Neighboring gene ribosomal protein L41 Neighboring gene proliferation-associated 2G4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Treiber T, et al. Mol Cell, 2017 Apr 20. PMID 28431233
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191090.1 → NP_001178019.1  zinc finger CCCH domain-containing protein 10

      See identical proteins and their annotated locations for NP_001178019.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KSE9, D3ZLM7
      Related
      ENSRNOP00000090698.1, ENSRNOT00000106284.2
      Conserved Domains (3) summary
      smart00356
      Location:40 → 62
      ZnF_C3H1; zinc finger
      pfam06005
      Location:243 → 279
      ZapB; Cell division protein ZapB
      pfam18345
      Location:140 → 158
      zf_CCCH_4; Zinc finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1557948..1562129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079910.2 → XP_038935838.1  zinc finger CCCH domain-containing protein 10 isoform X1

      UniProtKB/TrEMBL
      A6KSE9, D3ZLM7
      Conserved Domains (3) summary
      smart00356
      Location:40 → 62
      ZnF_C3H1; zinc finger
      pfam06005
      Location:243 → 279
      ZapB; Cell division protein ZapB
      pfam18345
      Location:140 → 158
      zf_CCCH_4; Zinc finger domain

    2. XM_039079909.2 → XP_038935837.1  zinc finger CCCH domain-containing protein 10 isoform X1

      UniProtKB/TrEMBL
      A6KSE9, D3ZLM7
      Conserved Domains (3) summary
      smart00356
      Location:40 → 62
      ZnF_C3H1; zinc finger
      pfam06005
      Location:243 → 279
      ZapB; Cell division protein ZapB
      pfam18345
      Location:140 → 158
      zf_CCCH_4; Zinc finger domain

    3. XM_008765041.4 → XP_008763263.1  zinc finger CCCH domain-containing protein 10 isoform X1

      See identical proteins and their annotated locations for XP_008763263.1

      UniProtKB/TrEMBL
      A6KSE9, D3ZLM7
      Related
      ENSRNOP00000105235.1, ENSRNOT00000142689.1
      Conserved Domains (3) summary
      smart00356
      Location:40 → 62
      ZnF_C3H1; zinc finger
      pfam06005
      Location:243 → 279
      ZapB; Cell division protein ZapB
      pfam18345
      Location:140 → 158
      zf_CCCH_4; Zinc finger domain

    4. XM_017595116.3 → XP_017450605.1  zinc finger CCCH domain-containing protein 10 isoform X1

      UniProtKB/TrEMBL
      A6KSE9, D3ZLM7
      Related
      ENSRNOP00000058705.2, ENSRNOT00000061995.5
      Conserved Domains (3) summary
      smart00356
      Location:40 → 62
      ZnF_C3H1; zinc finger
      pfam06005
      Location:243 → 279
      ZapB; Cell division protein ZapB
      pfam18345
      Location:140 → 158
      zf_CCCH_4; Zinc finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

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