Nudt13 nudix hydrolase 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nudt13provided by RGD
Official Full Name: nudix hydrolase 13provided by RGD
Primary source: RGD:1592767
See related: EnsemblRapid:ENSRNOG00000048195 AllianceGenome:RGD:1592767
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NADH pyrophosphatase activity. Predicted to be involved in NADH metabolic process and NADP catabolic process. Predicted to be located in mitochondrion. Orthologous to human NUDT13 (nudix hydrolase 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 76.8), Heart (RPKM 72.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (4050979..4071605, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (4001787..4022404, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (4434341..4454871, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH129000 (e-PCR)
- UniSTS:212308

AU028738 (e-PCR)
- UniSTS:112035

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables NADH pyrophosphatase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADH metabolic process	ISO Inferred from Sequence Orthology more info
involved_in NADP catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NAD(P)H pyrophosphatase NUDT13, mitochondrial

Names: nucleoside diphosphate linked moiety X motif 13; nudix (nucleoside diphosphate linked moiety X)-type motif 13; nudix-type motif 13

NP_001121108.1

EC 3.6.1.22

XP_038949586.1

EC 3.6.1.22

XP_063130707.1

EC 3.6.1.22

XP_063130708.1

EC 3.6.1.22

XP_063130709.1

EC 3.6.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127636.1 → NP_001121108.1 NAD(P)H pyrophosphatase NUDT13, mitochondrial

See identical proteins and their annotated locations for NP_001121108.1

Status: PROVISIONAL

Source sequence(s)

BC166528

UniProtKB/TrEMBL

B2GV51, M0R515

Related

ENSRNOP00000064470.1, ENSRNOT00000070933.4

Conserved Domains (4) summary

COG2816
Location:31 → 343

NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

cd03429
Location:200 → 344

NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...

pfam09296
Location:46 → 162

NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain

pfam09297
Location:166 → 195

zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

4050979..4071605 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093658.2 → XP_038949586.1 NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

Conserved Domains (1) summary

pfam09296
Location:47 → 158

NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
XM_063274638.1 → XP_063130708.1 NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X2
XM_063274639.1 → XP_063130709.1 NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X3
XM_063274637.1 → XP_063130707.1 NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X1