Flrt3 fibronectin leucine rich transmembrane protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Flrt3provided by RGD
Official Full Name: fibronectin leucine rich transmembrane protein 3provided by RGD
Primary source: RGD:1566005
See related: EnsemblRapid:ENSRNOG00000004874 AllianceGenome:RGD:1566005
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566005
Summary: Predicted to enable chemorepellent activity; fibroblast growth factor receptor binding activity; and protein homodimerization activity. Involved in neuron projection extension and response to axon injury. Acts upstream of or within axon guidance. Located in axon terminus and synaptic membrane. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 21 with or without anosmia. Orthologous to human FLRT3 (fibronectin leucine rich transmembrane protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 188.4), Brain (RPKM 85.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (148448115..148461458, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (127994491..128008137, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (134684446..134696586, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that FLRT3 is produced by injured DRG neurons and increases neuronal excitability in the dorsal horn, leading to pain sensitization. Neuropathic pain induction is a novel function of FLRT3.
Title: Increased Expression of Fibronectin Leucine-Rich Transmembrane Protein 3 in the Dorsal Root Ganglion Induces Neuropathic Pain in Rats.
Study concludes that FLRT3 codes for a putative cell surface receptor implicated in both the development of the nervous system and in the regeneration of the peripheral nervous system.
Title: FLRT3 is expressed in sensory neurons after peripheral nerve injury and regulates neurite outgrowth.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemorepellent activity	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in head development	ISO Inferred from Sequence Orthology more info
involved_in head development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in proepicardium cell migration involved in pericardium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in proepicardium cell migration involved in pericardium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to axon injury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat transmembrane protein FLRT3

Names: fibronectin-like domain-containing leucine-rich transmembrane protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126291.1 → NP_001119763.1 leucine-rich repeat transmembrane protein FLRT3 precursor

See identical proteins and their annotated locations for NP_001119763.1

Status: PROVISIONAL

Source sequence(s)

BC160843

UniProtKB/Swiss-Prot

B1H234

Related

ENSRNOP00000089101.1, ENSRNOT00000115709.2

Conserved Domains (8) summary

smart00013
Location:31 → 61

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:305 → 356

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:109 → 327

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:61 → 84

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:85 → 104

LRR_RI; leucine-rich repeat [structural motif]

pfam00041
Location:413 → 478

fn3; Fibronectin type III domain

pfam12799
Location:61 → 100

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:247 → 306

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

148448115..148461458 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105601.2 → XP_038961529.1 leucine-rich repeat transmembrane protein FLRT3 isoform X1

UniProtKB/TrEMBL

A0A0H2UHD5

Conserved Domains (5) summary

PRK15370
Location:44 → 306

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:277 → 349

PCC; polycystin cation channel protein

sd00031
Location:61 → 84

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:85 → 104

LRR_RI; leucine-rich repeat [structural motif]

cl21522
Location:413 → 478

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...