Zfp445 zinc finger protein 445 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp445provided by RGD
Official Full Name: zinc finger protein 445provided by RGD
Primary source: RGD:1559144
See related: EnsemblRapid:ENSRNOG00000025554 AllianceGenome:RGD:1559144
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1559144
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and double-stranded DNA binding activity. Predicted to be involved in epigenetic programing of female pronucleus; negative regulation of gene expression via chromosomal CpG island methylation; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF445 (zinc finger protein 445). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 245.5), Thymus (RPKM 239.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (131331795..131350749, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (122453175..122473355, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (131885119..131904303, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH132319 (e-PCR)
- UniSTS:215602

RH143629 (e-PCR)
- UniSTS:232875

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables double-stranded methylated DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epigenetic programing of female pronucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression via chromosomal CpG island methylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein 445

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191802.1 → NP_001178731.1 zinc finger protein 445

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

D3ZAK3

Related

ENSRNOP00000036378.5, ENSRNOT00000034690.7

Conserved Domains (8) summary

smart00431
Location:49 → 161

SCAN; leucine rich region

smart00349
Location:213 → 271

KRAB; krueppel associated box

COG5048
Location:536 → 962

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:626 → 646

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:844 → 864

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:213 → 252

KRAB; KRAB box

pfam02023
Location:49 → 137

SCAN; SCAN domain

pfam13465
Location:723 → 745

zf-H2C2_2; Zinc-finger double domain