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    Helb DNA helicase B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500837, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Helbprovided by RGD
    Official Full Name
    DNA helicase Bprovided by RGD
    Primary source
    RGD:1560103
    See related
    EnsemblRapid:ENSRNOG00000004189 AllianceGenome:RGD:1560103
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560103
    Summary
    Predicted to enable 5'-3' DNA helicase activity; RNA binding activity; and single-stranded DNA helicase activity. Predicted to be involved in DNA damage response; DNA replication, synthesis of primer; and regulation of DNA metabolic process. Predicted to act upstream of or within DNA duplex unwinding and DNA-templated DNA replication. Predicted to be located in several cellular components, including mitochondrion; nuclear body; and site of double-strand break. Predicted to be part of DNA replication factor A complex and spliceosomal complex. Orthologous to human HELB (DNA helicase B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 120.2), Spleen (RPKM 88.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Helb in Genome Data Viewer
    Location:
    7q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (57474115..57502221, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (55588510..55615979, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (64860641..64888146, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glutamate receptor interacting protein 1 Neighboring gene uncharacterized LOC134479877 Neighboring gene uncharacterized LOC120093802 Neighboring gene interleukin-1 receptor-associated kinase 3 Neighboring gene transmembrane BAX inhibitor motif containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage foci. Gu J, et al. Mol Biol Cell, 2004 Jul. PMID 15146062, Free PMC Article
    2. Molecular cloning of a cDNA encoding mouse DNA helicase B, which has homology to Escherichia coli RecD protein, and identification of a mutation in the DNA helicase B from tsFT848 temperature-sensitive DNA replication mutant cells. Tada S, et al. Nucleic Acids Res, 2001 Sep 15. PMID 11557815, Free PMC Article
    3. A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication. Taneja P, et al. J Biol Chem, 2002 Oct 25. PMID 12181327
    4. HELB Is a Feedback Inhibitor of DNA End Resection. Tkáč J, et al. Mol Cell, 2016 Feb 4. PMID 26774285
    5. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5'-3' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication, synthesis of primer ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA double-strand break processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor A complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA helicase B
    Names
    helicase (DNA) B
    NP_001386765.1
    XP_006241490.1
    XP_017450702.1
    XP_063120173.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399836.1 → NP_001386765.1  DNA helicase B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6IGX3, D4AAN8
      Related
      ENSRNOP00000029882.5, ENSRNOT00000038147.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      57474115..57502221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595213.3 → XP_017450702.1  DNA helicase B isoform X1

    2. XM_006241428.5 → XP_006241490.1  DNA helicase B isoform X2

      See identical proteins and their annotated locations for XP_006241490.1

      Conserved Domains (3) summary
      TIGR01448
      Location:86 → 728
      recD_rel; helicase, putative, RecD/TraA family
      cl21455
      Location:242 → 441
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl22977
      Location:661 → 707
      UvrD_C_2; UvrD-like helicase C-terminal domain

    3. XM_063264103.1 → XP_063120173.1  DNA helicase B isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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