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    Slc10a7 solute carrier family 10, member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291942, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc10a7provided by RGD
    Official Full Name
    solute carrier family 10, member 7provided by RGD
    Primary source
    RGD:1564388
    See related
    EnsemblRapid:ENSRNOG00000011991 AllianceGenome:RGD:1564388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P7
    Summary
    Predicted to enable bile acid transmembrane transporter activity. Predicted to be involved in several processes, including glycoprotein transport; heparin biosynthetic process; and intracellular calcium ion homeostasis. Located in endoplasmic reticulum and plasma membrane. Orthologous to human SLC10A7 (solute carrier family 10 member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 54.8), Lung (RPKM 54.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Slc10a7 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (46087440..46311753, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (29183143..29407470, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (32857984..33081359, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483636 Neighboring gene LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene U4 spliceosomal RNA Neighboring gene reeler domain containing 1 Neighboring gene large ribosomal subunit protein eL28-like Neighboring gene Rbmx like 1 Neighboring gene 60S ribosomal protein L21-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity  
    enables symporter activity  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport  
    involved_in bone development  
    involved_in heparin biosynthetic process  
    involved_in intracellular calcium ion homeostasis  
    involved_in sodium ion transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    sodium/bile acid cotransporter 7
    Names
    Na(+)/bile acid cotransporter 7
    solute carrier family 10 (sodium/bile acid cotransporter family), member 7
    solute carrier family 10 (sodium/bile acid cotransporter family), member 7-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010948.2NP_001010948.1  sodium/bile acid cotransporter 7

      See identical proteins and their annotated locations for NP_001010948.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q5PT50
      UniProtKB/TrEMBL
      A0A8L2Q8N4, A6IYJ4
      Related
      ENSRNOP00000015985.8, ENSRNOT00000015985.9
      Conserved Domains (1) summary
      pfam13593
      Location:10320
      SBF_like; SBF-like CPA transporter family (DUF4137)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      46087440..46311753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097586.2XP_038953514.1  sodium/bile acid cotransporter 7 isoform X3

      Conserved Domains (1) summary
      cl19217
      Location:10249
      SBF; Sodium Bile acid symporter family
    2. XM_039097585.2XP_038953513.1  sodium/bile acid cotransporter 7 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q8N4
      Related
      ENSRNOP00000077134.2, ENSRNOT00000097147.2
      Conserved Domains (1) summary
      pfam13593
      Location:10307
      SBF_like; SBF-like CPA transporter family (DUF4137)
    3. XM_063277890.1XP_063133960.1  sodium/bile acid cotransporter 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AJM8
    4. XM_063277889.1XP_063133959.1  sodium/bile acid cotransporter 7 isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q8N4
      Related
      ENSRNOP00000107182.1, ENSRNOT00000147369.1
    5. XM_063277891.1XP_063133961.1  sodium/bile acid cotransporter 7 isoform X5

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