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    S1pr2 sphingosine-1-phosphate receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29415, updated on 9-Dec-2024

    Summary

    Official Symbol
    S1pr2provided by RGD
    Official Full Name
    sphingosine-1-phosphate receptor 2provided by RGD
    Primary source
    RGD:68334
    See related
    EnsemblRapid:ENSRNOG00000020653 AllianceGenome:RGD:68334
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Edg5; H218; GPCR18; Gpcr13; snGPCR18
    Summary
    Enables G protein-coupled peptide receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway; negative regulation of smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in postsynapse. Predicted to be active in several cellular components, including glutamatergic synapse; plasma membrane; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 99.8), Heart (RPKM 92.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See S1pr2 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (27779452..27790344, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19503276..19514169, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (21984914..21995806, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 1 Neighboring gene spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP, pseudogene 1 Neighboring gene cytochrome c, somatic pseudogene Neighboring gene mitochondrial ribosomal protein L4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway  
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in excitatory postsynaptic potential  
    acts_upstream_of excitatory postsynaptic potential  
    involved_in filopodium assembly  
    involved_in filopodium assembly  
    involved_in negative regulation of excitatory postsynaptic potential  
    acts_upstream_of_or_within negative regulation of excitatory postsynaptic potential  
    acts_upstream_of_or_within negative regulation of smooth muscle cell migration PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation PubMed 
    involved_in positive regulation of establishment of endothelial barrier  
    involved_in positive regulation of establishment of endothelial barrier  
    involved_in positive regulation of peptidyl-threonine phosphorylation  
    involved_in regulation of metabolic process  
    involved_in regulation of postsynapse assembly  
    involved_in regulation of postsynapse assembly  
    involved_in sphingosine-1-phosphate receptor signaling pathway  
    involved_in sphingosine-1-phosphate receptor signaling pathway  
    involved_in sphingosine-1-phosphate receptor signaling pathway  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynapse  
    located_in presynapse  
    is_active_in presynapse  

    General protein information

    Preferred Names
    sphingosine 1-phosphate receptor 2
    Names
    AGR16
    G-protein coupled receptor 13
    G-protein coupled receptor H218
    S1P receptor 2
    S1P receptor Edg-5
    S1P2
    endothelial differentiation G-protein coupled receptor 5
    endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
    sphingosine 1-phosphate receptor Edg-5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017192.2NP_058888.1  sphingosine 1-phosphate receptor 2

      See identical proteins and their annotated locations for NP_058888.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P47752, Q54AI6
      UniProtKB/TrEMBL
      A0A8L2QF47, A6JNM8
      Related
      ENSRNOP00000111338.1, ENSRNOT00000137931.1
      Conserved Domains (2) summary
      pfam00001
      Location:50288
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:51299
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      27779452..27790344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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