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    Ei24 EI24, autophagy associated transmembrane protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300514, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ei24provided by RGD
    Official Full Name
    EI24, autophagy associated transmembrane proteinprovided by RGD
    Primary source
    RGD:1309868
    See related
    EnsemblRapid:ENSRNOG00000030391 AllianceGenome:RGD:1309868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable importin-alpha family protein binding activity. Predicted to be involved in macroautophagy. Predicted to act upstream of or within several processes, including cellular response to UV-C; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of protein import into nucleus. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in endoplasmic reticulum. Orthologous to human EI24 (EI24 autophagy associated transmembrane protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 381.9), Adrenal (RPKM 232.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ei24 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (44683138..44699502, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (36494289..36510653, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39254883..39271238, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene checkpoint kinase 1 Neighboring gene STT3 oligosaccharyltransferase complex catalytic subunit A Neighboring gene fasciculation and elongation protein zeta 1 Neighboring gene 60S ribosomal protein L14 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC112713

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in cytosol  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in membrane  
    located_in nuclear membrane  

    General protein information

    Preferred Names
    etoposide-induced protein 2.4 homolog
    Names
    etoposide induced 2.4 mRNA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025660.2NP_001020831.1  etoposide-induced protein 2.4 homolog

      See identical proteins and their annotated locations for NP_001020831.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4KM77
      UniProtKB/TrEMBL
      A0A8L2QNF3, A6KRM7
      Conserved Domains (1) summary
      pfam07264
      Location:120254
      EI24; Etoposide-induced protein 2.4 (EI24)
    2. NM_001433200.1NP_001420129.1  etoposide-induced protein 2.4 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4KM77
      UniProtKB/TrEMBL
      A0A8L2QNF3, A6KRM7
    3. NM_001433201.1NP_001420130.1  etoposide-induced protein 2.4 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4KM77
      UniProtKB/TrEMBL
      A0A8L2QNF3, A6KRM7
    4. NM_001433202.1NP_001420131.1  etoposide-induced protein 2.4 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4KM77
      UniProtKB/TrEMBL
      A0A8L2QNF3, A6KRM7
    5. NM_001433208.1NP_001420137.1  etoposide-induced protein 2.4 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4KM77
      UniProtKB/TrEMBL
      A0A8L2QNF3, A6KRM7
    6. NM_001433209.1NP_001420138.1  etoposide-induced protein 2.4 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4KM77
      UniProtKB/TrEMBL
      A0A8L2QNF3, A6KRM7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      44683138..44699502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242800.5XP_006242862.1  etoposide-induced protein 2.4 homolog isoform X1

      Conserved Domains (1) summary
      pfam07264
      Location:120254
      EI24; Etoposide-induced protein 2.4 (EI24)
    2. XM_006242801.5XP_006242863.1  etoposide-induced protein 2.4 homolog isoform X1

      Related
      ENSRNOP00000042710.5, ENSRNOT00000046590.6
      Conserved Domains (1) summary
      pfam07264
      Location:120254
      EI24; Etoposide-induced protein 2.4 (EI24)
    3. XM_039081024.2XP_038936952.1  etoposide-induced protein 2.4 homolog isoform X1

      Conserved Domains (1) summary
      pfam07264
      Location:120254
      EI24; Etoposide-induced protein 2.4 (EI24)
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