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    L3mbtl3 L3MBTL histone methyl-lysine binding protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309550, updated on 9-Dec-2024

    Summary

    Official Symbol
    L3mbtl3provided by RGD
    Official Full Name
    L3MBTL histone methyl-lysine binding protein 3provided by RGD
    Primary source
    RGD:1305474
    See related
    EnsemblRapid:ENSRNOG00000011720 AllianceGenome:RGD:1305474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including histone binding activity; identical protein binding activity; and methylation-dependent protein binding activity. Predicted to be involved in negative regulation of DNA-templated transcription; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of DNA methylation-dependent heterochromatin formation. Predicted to act upstream of or within erythrocyte maturation; granulocyte differentiation; and macrophage differentiation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Orthologous to human L3MBTL3 (L3MBTL histone methyl-lysine binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 77.3), Thymus (RPKM 56.1) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See L3mbtl3 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (20807679..20908609)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (18988763..19089247)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (19998776..20097298)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 18 Neighboring gene LSM5 homolog, U6 small nuclear RNA associated Neighboring gene cytochrome b-c1 complex subunit 10-like Neighboring gene ribosomal protein S10 like 2 Neighboring gene tumor protein, translationally-controlled 1 like 3 Neighboring gene sterile alpha motif domain containing 3 Neighboring gene transmembrane protein 200A Neighboring gene RNA, U11 small nuclear 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding  
    enables chromatin binding  
    enables histone binding  
    enables identical protein binding  
    enables methylation-dependent protein binding  
    enables zinc ion binding  
    Component Evidence Code Pubs
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    lethal(3)malignant brain tumor-like protein 3
    Names
    L3MBTL3, histone methyl-lysine binding protein
    l(3)mbt-like 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432316.1NP_001419245.1  lethal(3)malignant brain tumor-like protein 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZZG3, A0A8I6ADW7
    2. NM_001432318.1NP_001419247.1  lethal(3)malignant brain tumor-like protein 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZZG3, A0A8I6ADW7
    3. NM_001432319.1NP_001419248.1  lethal(3)malignant brain tumor-like protein 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ADW7, A0A8I6AH98
    4. NM_001432320.1NP_001419249.1  lethal(3)malignant brain tumor-like protein 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ADW7, A0A8I6AH98
    5. NM_001432321.1NP_001419250.1  lethal(3)malignant brain tumor-like protein 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ADW7, A0A8I6AH98

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      20807679..20908609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276392.1XP_063132462.1  lethal(3)malignant brain tumor-like protein 3 isoform X2

    2. XM_006227696.5XP_006227758.1  lethal(3)malignant brain tumor-like protein 3 isoform X1

      Conserved Domains (2) summary
      cd09582
      Location:793858
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:450542
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    3. XM_063276409.1XP_063132479.1  lethal(3)malignant brain tumor-like protein 3 isoform X2

    4. XM_006227695.5XP_006227757.1  lethal(3)malignant brain tumor-like protein 3 isoform X1

      Conserved Domains (2) summary
      cd09582
      Location:793858
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:450542
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    5. XM_039098998.2XP_038954926.1  lethal(3)malignant brain tumor-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZG3, A0A8I6ADW7
      Conserved Domains (2) summary
      cd09582
      Location:793858
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:450542
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    6. XM_039098996.2XP_038954924.1  lethal(3)malignant brain tumor-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZG3, A0A8I6ADW7
      Conserved Domains (2) summary
      cd09582
      Location:793858
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:450542
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    7. XM_039098995.2XP_038954923.1  lethal(3)malignant brain tumor-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZG3, A0A8I6ADW7
      Conserved Domains (2) summary
      cd09582
      Location:793858
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:450542
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    8. XM_063276402.1XP_063132472.1  lethal(3)malignant brain tumor-like protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADW7, A0A8I6AH98
    9. XM_039099000.2XP_038954928.1  lethal(3)malignant brain tumor-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZG3, A0A8I6ADW7
      Related
      ENSRNOP00000058121.4, ENSRNOT00000061404.6
      Conserved Domains (2) summary
      cd09582
      Location:793858
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:450542
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    10. XM_039098994.2XP_038954922.1  lethal(3)malignant brain tumor-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZG3, A0A8I6ADW7
      Conserved Domains (2) summary
      cd09582
      Location:793858
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:450542
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    11. XM_003748666.6XP_003748714.1  lethal(3)malignant brain tumor-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_003748714.1

      UniProtKB/TrEMBL
      A0A8I5ZZG3, A0A8I6ADW7
      Conserved Domains (2) summary
      cd09582
      Location:793858
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:450542
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    12. XM_039099003.2XP_038954931.1  lethal(3)malignant brain tumor-like protein 3 isoform X2

      Related
      ENSRNOP00000083485.2, ENSRNOT00000118212.2
      Conserved Domains (2) summary
      cd09582
      Location:768833
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:425517
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    13. XM_006227697.5XP_006227759.1  lethal(3)malignant brain tumor-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006227759.1

      UniProtKB/TrEMBL
      A0A8I5ZZG3, A0A8I6ADW7
      Conserved Domains (2) summary
      cd09582
      Location:793858
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:450542
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    14. XM_006227699.5XP_006227761.1  lethal(3)malignant brain tumor-like protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ADW7, D3ZJT9
      Conserved Domains (3) summary
      cd09582
      Location:742807
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00454
      Location:742808
      SAM; Sterile alpha motif
      smart00561
      Location:399491
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    15. XM_039099013.2XP_038954941.1  lethal(3)malignant brain tumor-like protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ADW7
      Conserved Domains (2) summary
      cd09582
      Location:717782
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:374466
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

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