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    Casz1 castor zinc finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313713, updated on 9-Dec-2024

    Summary

    Official Symbol
    Casz1provided by RGD
    Official Full Name
    castor zinc finger 1provided by RGD
    Primary source
    RGD:1563533
    See related
    EnsemblRapid:ENSRNOG00000013474 AllianceGenome:RGD:1563533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563533
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of neuron differentiation. Predicted to act upstream of or within negative regulation of cell differentiation and retina morphogenesis in camera-type eye. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CASZ1 (castor zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 43.7), Heart (RPKM 32.4) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Casz1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (164527083..164677037)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (159243965..159393935)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (165625119..165777053)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692510 Neighboring gene ribosomal protein L36, pseudogene Neighboring gene uncharacterized LOC120103035 Neighboring gene uncharacterized LOC120103036 Neighboring gene peroxisomal biogenesis factor 14 Neighboring gene DNA fragmentation factor subunit alpha

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of cell differentiation  
    acts_upstream_of_or_within negative regulation of amacrine cell differentiation  
    acts_upstream_of_or_within negative regulation of glial cell differentiation  
    acts_upstream_of_or_within negative regulation of neuron differentiation  
    acts_upstream_of_or_within negative regulation of retinal cone cell fate commitment  
    acts_upstream_of neuron differentiation  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of radial glial cell differentiation  
    involved_in regulation of neuron differentiation  
    acts_upstream_of_or_within retinal bipolar neuron differentiation  
    acts_upstream_of_or_within retinal rod cell fate commitment  
    Component Evidence Code Pubs
    located_in chromatin  
    located_in cytosol  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    zinc finger protein castor homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427668.2NP_001414597.1  zinc finger protein castor homolog 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZS43, A6IU91
      Related
      ENSRNOP00000079561.2, ENSRNOT00000103298.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      164527083..164677037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764318.4XP_008762540.1  zinc finger protein castor homolog 1 isoform X2

      UniProtKB/TrEMBL
      A6IU91
      Related
      ENSRNOP00000081497.2, ENSRNOT00000109654.2
      Conserved Domains (1) summary
      PHA03247
      Location:7641157
      PHA03247; large tegument protein UL36; Provisional
    2. XM_017593879.3XP_017449368.1  zinc finger protein castor homolog 1 isoform X2

      UniProtKB/TrEMBL
      A6IU91
      Conserved Domains (1) summary
      PHA03247
      Location:7641157
      PHA03247; large tegument protein UL36; Provisional
    3. XM_008764317.4XP_008762539.1  zinc finger protein castor homolog 1 isoform X1

      UniProtKB/TrEMBL
      A6IU91
      Conserved Domains (1) summary
      PHA03247
      Location:7881181
      PHA03247; large tegument protein UL36; Provisional
    4. XM_017593880.3XP_017449369.1  zinc finger protein castor homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGF7, A6IU91
      Related
      ENSRNOP00000091853.1, ENSRNOT00000094206.2
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