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    Sfrp2 secreted frizzled-related protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310552, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sfrp2provided by RGD
    Official Full Name
    secreted frizzled-related protein 2provided by RGD
    Primary source
    RGD:735163
    See related
    EnsemblRapid:ENSRNOG00000009465 AllianceGenome:RGD:735163
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including Wnt-protein binding activity; fibronectin binding activity; and signaling receptor binding activity. Involved in negative regulation of canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; and response to nutrient. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular space. Biomarker of myocardial infarction. Orthologous to human SFRP2 (secreted frizzled related protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 113.9), Uterus (RPKM 98.3) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Sfrp2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (171387536..171395081)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (169089517..169097064)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (182723732..182731277)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100855 Neighboring gene uncharacterized LOC120100856 Neighboring gene uncharacterized LOC134485791 Neighboring gene toll-like receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Wnt-protein binding  
    enables Wnt-protein binding  
    enables endopeptidase activator activity  
    enables enzyme activator activity  
    enables fibronectin binding  
    enables integrin binding  
    enables receptor ligand activity  
    Items 1 - 25 of 70
    Process Evidence Code Pubs
    acts_upstream_of BMP signaling pathway  
    acts_upstream_of_or_within Wnt signaling pathway involved in somitogenesis  
    acts_upstream_of_or_within anterior/posterior pattern specification  
    acts_upstream_of_or_within apoptotic process  
    involved_in branching involved in blood vessel morphogenesis  
    involved_in canonical Wnt signaling pathway  
    acts_upstream_of canonical Wnt signaling pathway  
    involved_in cardiac left ventricle morphogenesis  
    acts_upstream_of cardiac muscle cell apoptotic process  
    acts_upstream_of_or_within cartilage development  
    involved_in cell-cell signaling  
    involved_in cellular response to X-ray  
    acts_upstream_of_or_within chondrocyte development  
    acts_upstream_of_or_within collagen fibril organization  
    acts_upstream_of_or_within convergent extension involved in axis elongation  
    acts_upstream_of_or_within development of primary male sexual characteristics  
    acts_upstream_of_or_within digestive tract morphogenesis  
    acts_upstream_of_or_within embryonic digit morphogenesis  
    involved_in hematopoietic stem cell proliferation  
    acts_upstream_of_or_within male gonad development  
    acts_upstream_of mesodermal cell fate specification  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway  
    involved_in negative regulation of DNA-templated transcription  
    acts_upstream_of_or_within negative regulation of JUN kinase activity  
    involved_in negative regulation of Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of dermatome development  
    involved_in negative regulation of epithelial cell proliferation  
    involved_in negative regulation of epithelial to mesenchymal transition  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  
    acts_upstream_of_or_within negative regulation of mesodermal cell fate specification  
    involved_in negative regulation of peptidyl-tyrosine phosphorylation  
    acts_upstream_of_or_within neural tube closure  
    acts_upstream_of_or_within neural tube development  
    involved_in non-canonical Wnt signaling pathway  
    involved_in outflow tract morphogenesis  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of canonical Wnt signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of cell adhesion mediated by integrin  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of endopeptidase activity  
    acts_upstream_of_or_within positive regulation of fat cell differentiation  
    acts_upstream_of_or_within positive regulation of osteoblast differentiation  
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within post-anal tail morphogenesis  
    involved_in regulation of Wnt signaling pathway  
    acts_upstream_of_or_within regulation of apoptotic process  
    acts_upstream_of_or_within regulation of cell population proliferation  
    acts_upstream_of_or_within regulation of establishment of planar polarity  
    involved_in regulation of midbrain dopaminergic neuron differentiation  
    involved_in regulation of neuron projection development  
    involved_in regulation of stem cell division  
    involved_in response to nutrient PubMed 
    involved_in response to xenobiotic stimulus  
    involved_in sclerotome development  
    acts_upstream_of_or_within somitogenesis  
    acts_upstream_of stem cell fate specification  
    Items 1 - 25 of 70
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix  
    is_active_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    secreted frizzled-related protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100700.1 → NP_001094170.1  secreted frizzled-related protein 2 precursor

      See identical proteins and their annotated locations for NP_001094170.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161900
      UniProtKB/TrEMBL
      B1WBV2, F7EPG0
      Related
      ENSRNOP00000012659.4, ENSRNOT00000012658.8
      Conserved Domains (2) summary
      cd07446
      Location:36 → 163
      CRD_SFRP2; Cysteine-rich domain of the secreted frizzled-related protein 2 (SFRP2), a regulator of Wnt activity
      cd03580
      Location:169 → 295
      NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      171387536..171395081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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