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    Syndig1 synapse differentiation inducing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362235, updated on 9-Dec-2024

    Summary

    Symbol
    Syndig1provided by RGD
    Full Name
    synapse differentiation inducing 1provided by RGD
    Primary source
    RGD:1310753
    See related
    EnsemblRapid:ENSRNOG00000031536 AllianceGenome:RGD:1310753
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DSPC2; Tmem90b; RGD1310753
    Summary
    Predicted to enable glutamate receptor binding activity and protein homodimerization activity. Involved in positive regulation of synapse assembly; regulation of postsynapse assembly; and synaptic vesicle clustering. Located in cell body; dendrite; and excitatory synapse. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human SYNDIG1 (synapse differentiation inducing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 161.7), Heart (RPKM 19.1) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Syndig1 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (158491474..158695174)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (138030995..138234646)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (145031427..145199273)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cystatin D Neighboring gene uncharacterized LOC134486463 Neighboring gene uncharacterized LOC102551848 Neighboring gene uncharacterized LOC120101729 Neighboring gene magnesium transporter NIPA1-like Neighboring gene calcineurin subunit B type 1-like Neighboring gene protein SET-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutamate receptor binding  
    enables glutamate receptor binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    NOT located_in Golgi membrane  
    located_in cell body PubMed 
    located_in dendritic shaft PubMed 
    located_in dendritic spine PubMed 
    located_in early endosome membrane  
    located_in early endosome membrane  
    is_active_in excitatory synapse  
    located_in excitatory synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynaptic density  
    located_in postsynaptic density  
    is_active_in postsynaptic density membrane  
    is_active_in postsynaptic density membrane PubMed 
    located_in postsynaptic density membrane  
    is_active_in synaptic vesicle membrane  
    located_in synaptic vesicle membrane  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    synapse differentiation-inducing gene protein 1
    Names
    dispanin subfamily C member 2
    transmembrane protein 90B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025020.1NP_001020191.1  synapse differentiation-inducing gene protein 1

      See identical proteins and their annotated locations for NP_001020191.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092131
      UniProtKB/Swiss-Prot
      Q58DZ9
      UniProtKB/TrEMBL
      A6K7G0
      Related
      ENSRNOP00000060788.2, ENSRNOT00000068210.5
      Conserved Domains (1) summary
      pfam04505
      Location:177242
      CD225; Interferon-induced transmembrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      158491474..158695174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591918.3XP_017447407.1  synapse differentiation-inducing gene protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q58DZ9
      UniProtKB/TrEMBL
      A6K7G0
      Conserved Domains (1) summary
      pfam04505
      Location:177242
      CD225; Interferon-induced transmembrane protein
    2. XM_039105481.2XP_038961409.1  synapse differentiation-inducing gene protein 1 isoform X2

      Conserved Domains (1) summary
      pfam04505
      Location:177206
      CD225; Interferon-induced transmembrane protein
    3. XM_039105477.2XP_038961405.1  synapse differentiation-inducing gene protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q58DZ9
      UniProtKB/TrEMBL
      A6K7G0
      Conserved Domains (1) summary
      pfam04505
      Location:177242
      CD225; Interferon-induced transmembrane protein
    4. XM_017591922.3XP_017447411.1  synapse differentiation-inducing gene protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q58DZ9
      UniProtKB/TrEMBL
      A6K7G0
      Conserved Domains (1) summary
      pfam04505
      Location:177242
      CD225; Interferon-induced transmembrane protein
    5. XM_017591916.3XP_017447405.1  synapse differentiation-inducing gene protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q58DZ9
      UniProtKB/TrEMBL
      A6K7G0
      Conserved Domains (1) summary
      pfam04505
      Location:177242
      CD225; Interferon-induced transmembrane protein
    6. XM_039105478.2XP_038961406.1  synapse differentiation-inducing gene protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q58DZ9
      UniProtKB/TrEMBL
      A6K7G0
      Conserved Domains (1) summary
      pfam04505
      Location:177242
      CD225; Interferon-induced transmembrane protein
    7. XM_039105480.2XP_038961408.1  synapse differentiation-inducing gene protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q58DZ9
      UniProtKB/TrEMBL
      A6K7G0
      Conserved Domains (1) summary
      pfam04505
      Location:177242
      CD225; Interferon-induced transmembrane protein
    8. XM_017591920.3XP_017447409.1  synapse differentiation-inducing gene protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q58DZ9
      UniProtKB/TrEMBL
      A6K7G0
      Conserved Domains (1) summary
      pfam04505
      Location:177242
      CD225; Interferon-induced transmembrane protein
    9. XM_017591912.3XP_017447401.1  synapse differentiation-inducing gene protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q58DZ9
      UniProtKB/TrEMBL
      A6K7G0
      Conserved Domains (1) summary
      pfam04505
      Location:177242
      CD225; Interferon-induced transmembrane protein
    10. XM_017591913.3XP_017447402.1  synapse differentiation-inducing gene protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q58DZ9
      UniProtKB/TrEMBL
      A6K7G0
      Conserved Domains (1) summary
      pfam04505
      Location:177242
      CD225; Interferon-induced transmembrane protein

    RNA

    1. XR_005501940.2 RNA Sequence

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