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    Adamtsl1 ADAMTS-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362539, updated on 9-Dec-2024

    Summary

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    Symbol
    Adamtsl1provided by RGD
    Full Name
    ADAMTS-like 1provided by RGD
    Primary source
    RGD:1306439
    See related
    EnsemblRapid:ENSRNOG00000006956 AllianceGenome:RGD:1306439
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AABR07049085.1
    Summary
    Predicted to be involved in extracellular matrix organization. Predicted to be located in extracellular region. Orthologous to human ADAMTSL1 (ADAMTS like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 168.3), Muscle (RPKM 45.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adamtsl1 in Genome Data Viewer
    Location:
    5q31
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (105010471..105965792)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (99964406..100919786)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (103789443..104753866)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A, pseudogene 11 Neighboring gene phosphoglycerate mutase 1, pseudogene 6 Neighboring gene SH3 domain containing GRB2 like 2, endophilin A1 Neighboring gene stabilizer of axonemal microtubules 1 Neighboring gene Ras-related GTP binding A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADAMTS-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431177.1 → NP_001418106.1  ADAMTS-like protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    2. NM_001431178.1 → NP_001418107.1  ADAMTS-like protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A1W2Q621

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      105010471..105965792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111084.2 → XP_038967012.1  ADAMTS-like protein 1 isoform X6

      Conserved Domains (5) summary
      smart00408
      Location:939 → 997
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:84 → 130
      TSP1; Thrombospondin type 1 repeats
      pfam19030
      Location:718 → 776
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cd00096
      Location:1352 → 1356
      Ig; Ig strand B [structural motif]
      cl11960
      Location:1336 → 1418
      Ig; Immunoglobulin domain

    2. XM_039111080.2 → XP_038967008.1  ADAMTS-like protein 1 isoform X2

      Conserved Domains (5) summary
      smart00408
      Location:922 → 980
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:84 → 130
      TSP1; Thrombospondin type 1 repeats
      pfam19030
      Location:701 → 759
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cd00096
      Location:1335 → 1339
      Ig; Ig strand B [structural motif]
      cl11960
      Location:1319 → 1401
      Ig; Immunoglobulin domain

    3. XM_039111079.2 → XP_038967007.1  ADAMTS-like protein 1 isoform X1

      UniProtKB/TrEMBL
      F1LWA1
      Related
      ENSRNOP00000055317.5, ENSRNOT00000058520.7
      Conserved Domains (6) summary
      smart00408
      Location:939 → 997
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:84 → 130
      TSP1; Thrombospondin type 1 repeats
      pfam08686
      Location:1778 → 1807
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:718 → 776
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cd00096
      Location:1352 → 1356
      Ig; Ig strand B [structural motif]
      cl11960
      Location:1336 → 1418
      Ig; Immunoglobulin domain

    4. XM_039111081.2 → XP_038967009.1  ADAMTS-like protein 1 isoform X3

      Conserved Domains (5) summary
      smart00408
      Location:891 → 949
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:36 → 82
      TSP1; Thrombospondin type 1 repeats
      pfam19030
      Location:670 → 728
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cd00096
      Location:1304 → 1308
      Ig; Ig strand B [structural motif]
      cl11960
      Location:1288 → 1370
      Ig; Immunoglobulin domain

    5. XM_039111082.2 → XP_038967010.1  ADAMTS-like protein 1 isoform X4

      Related
      ENSRNOP00000076109.2, ENSRNOT00000093462.3
      Conserved Domains (6) summary
      smart00408
      Location:891 → 949
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:36 → 82
      TSP1; Thrombospondin type 1 repeats
      pfam08686
      Location:1730 → 1759
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:670 → 728
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cd00096
      Location:1304 → 1308
      Ig; Ig strand B [structural motif]
      cl11960
      Location:1288 → 1370
      Ig; Immunoglobulin domain

    6. XM_039111083.2 → XP_038967011.1  ADAMTS-like protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A1W2Q6M9
      Related
      ENSRNOP00000076311.2, ENSRNOT00000093557.3
      Conserved Domains (6) summary
      smart00408
      Location:874 → 932
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:36 → 82
      TSP1; Thrombospondin type 1 repeats
      pfam08686
      Location:1713 → 1742
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:653 → 711
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cd00096
      Location:1287 → 1291
      Ig; Ig strand B [structural motif]
      cl11960
      Location:1271 → 1353
      Ig; Immunoglobulin domain

    7. XM_039111086.2 → XP_038967014.1  ADAMTS-like protein 1 isoform X7

      Conserved Domains (4) summary
      smart00408
      Location:423 → 481
      IGc2; Immunoglobulin C-2 Type
      pfam19030
      Location:202 → 260
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cd00096
      Location:836 → 840
      Ig; Ig strand B [structural motif]
      cl11960
      Location:820 → 902
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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