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    Dsc1 desmocollin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291759, updated on 9-Dec-2024

    Summary

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    Symbol
    Dsc1provided by RGD
    Full Name
    desmocollin 1provided by RGD
    Primary source
    RGD:1310768
    See related
    EnsemblRapid:ENSRNOG00000056258 AllianceGenome:RGD:1310768
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in desmosome. Orthologous to human DSC1 (desmocollin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 45.1), Testes (RPKM 20.3) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dsc1 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (11774711..11831868, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (11499936..11556801, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (11877918..11906828, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 2 Neighboring gene desmocollin 2 Neighboring gene leucine aminopeptidase 3, pseudogene 1 Neighboring gene ribosomal protein L3, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, et al. J Periodontal Res, 2011 Jun. PMID 21382035
    2. Assessment of splice variant-specific functions of desmocollin 1 in the skin. Cheng X, et al. Mol Cell Biol, 2004 Jan. PMID 14673151, Free PMC Article
    3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in desmosome maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of skin barrier IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hair follicle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in desmosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in desmosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    desmocollin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106161.3 → NP_001099631.2  desmocollin-1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2KA90, A0A8I6GE75
      Related
      ENSRNOP00000075307.2, ENSRNOT00000078207.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      11774711..11831868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097287.2 → XP_038953215.1  desmocollin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GE75
      Conserved Domains (3) summary
      cd11304
      Location:105 → 207
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam00028
      Location:216 → 319
      Cadherin; Cadherin domain
      pfam01049
      Location:704 → 747
      Cadherin_C; Cadherin cytoplasmic region

    2. XM_039097286.2 → XP_038953214.1  desmocollin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GE75
      Conserved Domains (3) summary
      cd11304
      Location:105 → 207
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam00028
      Location:216 → 319
      Cadherin; Cadherin domain
      pfam01049
      Location:704 → 747
      Cadherin_C; Cadherin cytoplasmic region
    Nucleotide Protein Strain
    Heading Accession and Version

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