Stn1 STN1 subunit of CST complex [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stn1provided by RGD
Official Full Name: STN1 subunit of CST complexprovided by RGD
Primary source: RGD:1305637
See related: EnsemblRapid:ENSRNOG00000020376 AllianceGenome:RGD:1305637
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Obfc1
Summary: Predicted to enable single-stranded telomeric DNA binding activity. Predicted to be involved in negative regulation of telomere maintenance via telomerase; positive regulation of DNA replication; and telomere maintenance via telomere lengthening. Predicted to be located in chromosome, telomeric region; intermediate filament cytoskeleton; and nuclear lumen. Predicted to be part of CST complex. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human STN1 (STN1 subunit of CST complex). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 43.8), Lung (RPKM 41.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (256336916..256371143, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (246391311..246429844, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (267281786..267315714, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables single-stranded telomeric DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded telomeric DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded telomeric DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in telomere capping	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in telomere maintenance via telomere lengthening	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via telomere lengthening	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance via telomere lengthening	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomere lengthening	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of CST complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CST complex	IEA Inferred from Electronic Annotation more info
part_of CST complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CST complex subunit STN1

Names: STN1, CST complex subunit; oligonucleotide/oligosaccharide-binding fold containing 1; oligonucleotide/oligosaccharide-binding fold-containing protein 1; suppressor of cdc thirteen homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011943.1 → NP_001011943.1 CST complex subunit STN1

See identical proteins and their annotated locations for NP_001011943.1

Status: PROVISIONAL

Source sequence(s)

BC079096

UniProtKB/Swiss-Prot

Q6AYD2

Conserved Domains (2) summary

cd04483
Location:65 → 165

hOBFC1_like; hOBFC1_like: A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which ...

pfam09170
Location:167 → 374

STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

256336916..256371143 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017589043.3 → XP_017444532.1 CST complex subunit STN1 isoform X1

UniProtKB/TrEMBL

A0A0H2UHR9, A0A8I6A2S8, A6JHQ6

Conserved Domains (2) summary

cd04483
Location:65 → 165

hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...

pfam09170
Location:167 → 340

STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
XM_006231474.5 → XP_006231536.1 CST complex subunit STN1 isoform X2

UniProtKB/TrEMBL

A0A8I6A2S8

Conserved Domains (2) summary

cd04483
Location:65 → 165

hOBFC1_like; hOBFC1_like: A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which ...

pfam09170
Location:167 → 342

STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
XM_039109088.2 → XP_038965016.1 CST complex subunit STN1 isoform X1

UniProtKB/TrEMBL

A0A0H2UHR9, A0A8I6A2S8, A6JHQ6

Conserved Domains (2) summary

cd04483
Location:65 → 165

hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...

pfam09170
Location:167 → 340

STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
XM_006231472.4 → XP_006231534.1 CST complex subunit STN1 isoform X1

See identical proteins and their annotated locations for XP_006231534.1

UniProtKB/TrEMBL

A0A0H2UHR9, A0A8I6A2S8, A6JHQ6

Related

ENSRNOP00000101153.1, ENSRNOT00000130024.1

Conserved Domains (2) summary

cd04483
Location:65 → 165

hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...

pfam09170
Location:167 → 340

STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
XM_006231475.5 → XP_006231537.1 CST complex subunit STN1 isoform X3

Conserved Domains (2) summary

pfam09170
Location:130 → 306

STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1

cl09930
Location:44 → 128

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
XM_039109099.2 → XP_038965027.1 CST complex subunit STN1 isoform X4

Conserved Domains (2) summary

cd04483
Location:65 → 165

hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...

pfam09170
Location:167 → 203

STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1