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    Slit2 slit guidance ligand 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360272, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slit2provided by RGD
    Official Full Name
    slit guidance ligand 2provided by RGD
    Primary source
    RGD:69310
    See related
    EnsemblRapid:ENSRNOG00000003840 AllianceGenome:RGD:69310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables heparan sulfate proteoglycan binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; negative regulation of monocyte chemotaxis; and nervous system development. Located in axon; dendrite; and neuronal cell body. Is active in perisynaptic extracellular matrix. Biomarker of anti-basement membrane glomerulonephritis; congenital diaphragmatic hernia; diabetic retinopathy; and transient cerebral ischemia. Orthologous to human SLIT2 (slit guidance ligand 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 163.7), Kidney (RPKM 132.8) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slit2 in Genome Data Viewer
    Location:
    14q11
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (66829661..67168517, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (62616337..62955934, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (66831848..67171491, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel interacting protein 4 Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 20 Neighboring gene parkin coregulated like Neighboring gene microRNA 218-1 Neighboring gene microRNA 3565 Neighboring gene 40S ribosomal protein S6 pseudogene Neighboring gene ribosomal protein S3a, pseudogene 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase inhibitor activity  
    enables GTPase inhibitor activity  
    enables Roundabout binding  
    enables Roundabout binding  
    enables calcium ion binding  
    enables chemorepellent activity  
    enables follicle-stimulating hormone receptor activity  
    enables heparan sulfate proteoglycan binding PubMed 
    enables heparin binding  
    enables heparin binding  
    enables identical protein binding  
    enables laminin-1 binding  
    enables laminin-1 binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables proteoglycan binding  
    enables proteoglycan binding  
    enables signaling receptor binding  
    Items 1 - 25 of 97
    Process Evidence Code Pubs
    involved_in Roundabout signaling pathway  
    involved_in Roundabout signaling pathway  
    involved_in animal organ development  
    involved_in aortic valve morphogenesis  
    involved_in apoptotic process involved in luteolysis  
    involved_in apoptotic process involved in luteolysis  
    involved_in axon extension involved in axon guidance  
    involved_in axon extension involved in axon guidance  
    involved_in axon guidance  
    acts_upstream_of_or_within axon guidance  
    involved_in axon guidance  
    acts_upstream_of_or_within axonogenesis  
    involved_in branching morphogenesis of an epithelial tube  
    involved_in branching morphogenesis of an epithelial tube  
    involved_in cell differentiation  
    involved_in cell migration involved in sprouting angiogenesis  
    involved_in cell migration involved in sprouting angiogenesis  
    acts_upstream_of_or_within cell-cell adhesion  
    involved_in cellular response to heparin  
    involved_in cellular response to heparin  
    involved_in cellular response to hormone stimulus  
    involved_in cellular response to hormone stimulus  
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus PubMed 
    NOT involved_in chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration  
    involved_in chemorepulsion involved in postnatal olfactory bulb interneuron migration  
    involved_in chemorepulsion involved in postnatal olfactory bulb interneuron migration  
    involved_in corticospinal neuron axon guidance through spinal cord  
    involved_in corticospinal neuron axon guidance through spinal cord  
    acts_upstream_of_or_within dorsal/ventral axon guidance  
    involved_in follicle-stimulating hormone signaling pathway  
    acts_upstream_of_or_within in utero embryonic development  
    involved_in induction of negative chemotaxis  
    involved_in induction of negative chemotaxis  
    acts_upstream_of_or_within kidney development  
    acts_upstream_of_or_within mammary duct terminal end bud growth  
    acts_upstream_of_or_within mammary gland duct morphogenesis  
    acts_upstream_of_or_within metanephros development  
    involved_in motor neuron axon guidance  
    involved_in motor neuron axon guidance  
    involved_in negative chemotaxis  
    acts_upstream_of_or_within negative chemotaxis  
    involved_in negative chemotaxis  
    involved_in negative regulation of actin filament polymerization  
    involved_in negative regulation of actin filament polymerization  
    acts_upstream_of_or_within negative regulation of axon extension  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell migration  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    involved_in negative regulation of cellular response to growth factor stimulus  
    involved_in negative regulation of cellular response to growth factor stimulus  
    involved_in negative regulation of chemokine-mediated signaling pathway  
    involved_in negative regulation of chemokine-mediated signaling pathway  
    involved_in negative regulation of endothelial cell migration  
    involved_in negative regulation of endothelial cell migration  
    acts_upstream_of_or_within negative regulation of gene expression  
    involved_in negative regulation of lamellipodium assembly  
    involved_in negative regulation of lamellipodium assembly  
    involved_in negative regulation of leukocyte chemotaxis  
    involved_in negative regulation of monocyte chemotaxis PubMed 
    involved_in negative regulation of mononuclear cell migration  
    involved_in negative regulation of mononuclear cell migration  
    involved_in negative regulation of neutrophil chemotaxis  
    involved_in negative regulation of neutrophil chemotaxis  
    involved_in negative regulation of protein phosphorylation  
    involved_in negative regulation of retinal ganglion cell axon guidance  
    involved_in negative regulation of retinal ganglion cell axon guidance  
    involved_in negative regulation of small GTPase mediated signal transduction  
    involved_in negative regulation of small GTPase mediated signal transduction  
    involved_in negative regulation of smooth muscle cell chemotaxis  
    involved_in negative regulation of smooth muscle cell chemotaxis  
    involved_in negative regulation of smooth muscle cell migration  
    involved_in negative regulation of vascular permeability  
    involved_in negative regulation of vascular permeability  
    involved_in nervous system development  
    involved_in neuron projection extension PubMed 
    acts_upstream_of_or_within neuron projection morphogenesis  
    acts_upstream_of_or_within olfactory bulb development  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of synapse assembly PubMed 
    involved_in pulmonary valve morphogenesis  
    involved_in response to cortisol  
    involved_in response to cortisol  
    involved_in response to nutrient levels PubMed 
    involved_in retinal ganglion cell axon guidance  
    acts_upstream_of_or_within retinal ganglion cell axon guidance  
    involved_in retinal ganglion cell axon guidance  
    involved_in spinal cord development PubMed 
    involved_in synapse maturation PubMed 
    involved_in synapse maturation PubMed 
    involved_in synapse maturation PubMed 
    acts_upstream_of_or_within telencephalon cell migration  
    involved_in ureteric bud development  
    involved_in ureteric bud development  
    involved_in ventricular septum morphogenesis  
    Items 1 - 25 of 97
    Component Evidence Code Pubs
    located_in axon PubMed 
    located_in cell body PubMed 
    located_in cell projection PubMed 
    located_in cell surface  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in dendrite PubMed 
    located_in extracellular region  
    located_in extracellular space  
    located_in extracellular space  
    located_in membrane  
    located_in neuronal cell body PubMed 
    is_active_in perisynaptic extracellular matrix PubMed 
    is_active_in perisynaptic extracellular matrix PubMed 
    is_active_in perisynaptic extracellular matrix PubMed 
    is_active_in perisynaptic extracellular matrix PubMed 

    General protein information

    Preferred Names
    slit homolog 2 protein
    Names
    slit-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022632.2NP_072154.2  slit homolog 2 protein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2KA49, F1MA79
      Related
      ENSRNOP00000005477.6, ENSRNOT00000005477.9
      Conserved Domains (10) summary
      smart00013
      Location:723754
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:855904
      LRRCT; Leucine rich repeat C-terminal domain
      smart00282
      Location:11791312
      LamG; Laminin G domain
      cd00054
      Location:10721108
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00116
      Location:43214
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:847859
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:3856
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01462
      Location:2754
      LRRNT; Leucine rich repeat N-terminal domain
      pfam12799
      Location:328368
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:773833
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      66829661..67168517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599277.3XP_017454766.1  slit homolog 2 protein isoform X3

      UniProtKB/TrEMBL
      A0A0G2KA49
    2. XM_039092141.2XP_038948069.1  slit homolog 2 protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6AMD5
      Related
      ENSRNOP00000094520.2, ENSRNOT00000098728.2
      Conserved Domains (10) summary
      TIGR00864
      Location:8321013
      PCC; polycystin cation channel protein
      smart00013
      Location:2758
      LRRNT; Leucine rich repeat N-terminal domain
      smart00282
      Location:11921325
      LamG; Laminin G domain
      cd00054
      Location:10851121
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00031
      Location:851863
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:3856
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:557854
      internalin_A; class 1 internalin InlA
      pfam00008
      Location:10021029
      EGF; EGF-like domain
      pfam12661
      Location:11391160
      hEGF; Human growth factor-like EGF
      pfam13855
      Location:778837
      LRR_8; Leucine rich repeat
    3. XM_017599278.3XP_017454767.1  slit homolog 2 protein isoform X4

      UniProtKB/TrEMBL
      A0A0G2KA49
    4. XM_063273311.1XP_063129381.1  slit homolog 2 protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6AMD5
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