U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Synm synemin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308709, updated on 9-Dec-2024

    Summary

    Official Symbol
    Synmprovided by RGD
    Official Full Name
    syneminprovided by RGD
    Primary source
    RGD:727872
    See related
    EnsemblRapid:ENSRNOG00000014030 AllianceGenome:RGD:727872
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dmn
    Summary
    Predicted to enable intermediate filament binding activity and vinculin binding activity. Predicted to be a structural constituent of cytoskeleton and structural constituent of muscle. Predicted to be involved in fast-twitch skeletal muscle fiber contraction. Located in intermediate filament. Orthologous to human SYNM (synemin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 843.0), Lung (RPKM 224.1) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Synm in Genome Data Viewer
    Location:
    1q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (130743891..130774254, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (121333712..121363652, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (128692112..128722048, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349234 Neighboring gene tetratricopeptide repeat domain 23 Neighboring gene uncharacterized LOC120099844 Neighboring gene small ribosomal subunit protein eS27-like Neighboring gene uncharacterized LOC134484899

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables intermediate filament binding  
    enables intermediate filament binding  
    enables structural constituent of cytoskeleton  
    enables structural constituent of cytoskeleton  
    enables structural constituent of muscle  
    enables structural constituent of muscle  
    enables vinculin binding  
    enables vinculin binding  
    Component Evidence Code Pubs
    is_active_in costamere  
    located_in costamere  
    is_active_in intermediate filament  
    located_in intermediate filament PubMed 
    located_in intermediate filament  
    located_in intermediate filament cytoskeleton  
    located_in membrane  
    is_active_in neurofilament cytoskeleton  
    located_in neurofilament cytoskeleton  
    is_active_in sarcolemma  
    located_in sarcolemma  

    General protein information

    Preferred Names
    synemin
    Names
    desmuslin
    synemin, intermediate filament protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134858.3NP_001128330.1  synemin

      See identical proteins and their annotated locations for NP_001128330.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JBT8, A6JBU1, G3V9G5
      Related
      ENSRNOP00000046923.3, ENSRNOT00000050832.6
      Conserved Domains (3) summary
      pfam00038
      Location:10318
      Filament; Intermediate filament protein
      pfam13801
      Location:79157
      Metal_resist; Heavy-metal resistance
      cl21478
      Location:177291
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      130743891..130774254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229337.4XP_006229399.1  synemin isoform X1

      See identical proteins and their annotated locations for XP_006229399.1

      UniProtKB/TrEMBL
      A0A096MK54, A6JBT7, Q810D0
      Related
      ENSRNOP00000068384.1, ENSRNOT00000076511.4
      Conserved Domains (2) summary
      pfam00038
      Location:10318
      Filament; Intermediate filament protein
      pfam13801
      Location:79157
      Metal_resist; Heavy-metal resistance

    External link. Please review our privacy policy.