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    Dis3l DIS3-like exosome 3'-5' exoribonuclease [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dis3lprovided by RGD
    Official Full Name
    DIS3-like exosome 3'-5' exoribonucleaseprovided by RGD
    Primary source
    RGD:1308959
    See related
    EnsemblRapid:ENSRNOG00000010537 AllianceGenome:RGD:1308959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308959
    Summary
    Predicted to enable enzyme binding activity and exoribonuclease II activity. Predicted to be involved in RNA processing; mRNA catabolic process; and rRNA catabolic process. Predicted to be located in centrosome; cytosol; and plasma membrane. Predicted to be part of cytoplasmic exosome (RNase complex). Orthologous to human DIS3L (DIS3 like exosome 3'-5' exoribonuclease). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 131.6), Kidney (RPKM 97.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dis3l in Genome Data Viewer
    Location:
    8q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (73699185..73735581, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (64803925..64840306, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (69771211..69807880, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon AGA) 48 Neighboring gene small Cajal body-specific RNA 14 Neighboring gene timeless interacting protein Neighboring gene multiple EGF-like-domains 11 Neighboring gene uncharacterized LOC134480194 Neighboring gene RAB11a, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Addition of poly(A) and poly(A)-rich tails during RNA degradation in the cytoplasm of human cells. Slomovic S, et al. Proc Natl Acad Sci U S A, 2010 Apr 20. PMID 20368444, Free PMC Article
    2. Dis3-like 1: a novel exoribonuclease associated with the human exosome. Staals RH, et al. EMBO J, 2010 Jul 21. PMID 20531389, Free PMC Article
    3. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. Tomecki R, et al. EMBO J, 2010 Jul 21. PMID 20531386, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94911

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3'-5'-RNA exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exoribonuclease II activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exoribonuclease II activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DIS3-like exonuclease 1
    Names
    DIS3 mitotic control homolog-like
    NP_001008381.2
    XP_006243325.1
    XP_008764533.1
    XP_017451228.1
    XP_063121836.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008380.2 → NP_001008381.2  DIS3-like exonuclease 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5U2P0
      UniProtKB/TrEMBL
      A6J5C1
      Related
      ENSRNOP00000014071.5, ENSRNOT00000014071.8
      Conserved Domains (3) summary
      COG0557
      Location:265 → 899
      VacB; Exoribonuclease R [Transcription]
      cd09862
      Location:11 → 188
      PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
      pfam17215
      Location:881 → 958
      Rrp44_S1; S1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      73699185..73735581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243263.5 → XP_006243325.1  DIS3-like exonuclease 1 isoform X1

      See identical proteins and their annotated locations for XP_006243325.1

      UniProtKB/TrEMBL
      A6J5C2
      Conserved Domains (3) summary
      COG0557
      Location:182 → 816
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:382 → 732
      RNB; RNB domain
      cl14812
      Location:2 → 105
      PIN_SF; PIN (PilT N terminus) domain: Superfamily

    2. XM_063265766.1 → XP_063121836.1  DIS3-like exonuclease 1 isoform X3

    3. XM_017595739.1 → XP_017451228.1  DIS3-like exonuclease 1 isoform X4

    4. XM_008766311.3 → XP_008764533.1  DIS3-like exonuclease 1 isoform X2

      Conserved Domains (3) summary
      COG0557
      Location:265 → 893
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:465 → 815
      RNB; RNB domain
      cl14812
      Location:12 → 188
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2P0.2 GenPept UniProtKB/Swiss-Prot:Q5U2P0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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