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    Lrp2 LDL receptor related protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29216, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lrp2provided by RGD
    Official Full Name
    LDL receptor related protein 2provided by RGD
    Primary source
    RGD:68407
    See related
    EnsemblRapid:ENSRNOG00000056184 AllianceGenome:RGD:68407
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including PDZ domain binding activity; insulin-like growth factor I binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including chemoattraction of axon; positive regulation of transport; and protein transport. Located in several cellular components, including apical plasma membrane; axonal growth cone; and brush border membrane. Part of receptor complex. Used to study hypertension. Biomarker of autosomal dominant polycystic kidney disease; end stage renal disease; membranous glomerulonephritis; and nephrosis. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 5350.7) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lrp2 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    79
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (74597148..74754535, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (54189305..54346769, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (55665153..55822484, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 11 Neighboring gene DNA mismatch repair protein Msh6-like Neighboring gene dehydrogenase/reductase 9 Neighboring gene cofilin 1, pseudogene 10 Neighboring gene uncharacterized LOC108350390

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hemoglobin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables insulin-like growth factor I binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables low-density lipoprotein particle receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in aorta development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within aorta development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemoattraction of axon IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in coronary artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in coronary artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in coronary artery morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cranial skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cranial skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within diol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytic hemoglobin import into cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in folate import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in folate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in folate import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within forebrain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male gonad development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in metal ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metal ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in metanephric proximal tubule development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endopeptidase activity IC
    Inferred by Curator
    more info
    PubMed 
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural tube closure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neural tube closure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection arborization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection arborization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection arborization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in outflow tract septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in outflow tract septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in outflow tract septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lipoprotein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lysosomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of oligodendrocyte progenitor proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of oligodendrocyte progenitor proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of oligodendrocyte progenitor proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pulmonary artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pulmonary artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pulmonary artery morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to X-ray IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to leptin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to leptin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to leptin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in secondary heart field specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in secondary heart field specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in secondary heart field specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of sound ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transcytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vagina development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vagina development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vagina development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ventricular compact myocardium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular compact myocardium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular compact myocardium morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ventricular septum development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vitamin D metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within vitamin D metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    low-density lipoprotein receptor-related protein 2
    Names
    LRP-2
    glycoprotein 330
    gp330
    low density lipoprotein-related protein 2
    megalin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030827.2NP_110454.2  low-density lipoprotein receptor-related protein 2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P98158
      UniProtKB/TrEMBL
      A0A0G2K9W7, A6HM07
      Related
      ENSRNOP00000075159.1, ENSRNOT00000082624.3
      Conserved Domains (11) summary
      smart00192
      Location:29072939
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:15021544
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:13911430
      EGF_CA; Calcium-binding EGF-like domain
      COG3391
      Location:21102302
      YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
      cd00112
      Location:37613795
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:10651101
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:18841928
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam12662
      Location:31343157
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:20232059
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      NF033759
      Location:27433131
      exchanger_TraA; outer membrane exchange protein TraA
      cl39070
      Location:837877
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      74597148..74754535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)