Cd74 CD74 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 25599, updated on 9-Dec-2024

Summary

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Official Symbol: Cd74provided by RGD
Official Full Name: CD74 moleculeprovided by RGD
Primary source: RGD:2313
See related: EnsemblRapid:ENSRNOG00000018735 AllianceGenome:RGD:2313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: INVG34
Summary: Predicted to enable several functions, including amyloid-beta binding activity; macrophage migration inhibitory factor binding activity; and signaling receptor binding activity. Predicted to contribute to cytokine binding activity. Involved in positive regulation of MAPK cascade. Predicted to be located in several cellular components, including external side of plasma membrane; lysosome; and multivesicular body. Predicted to be part of MHC class II protein complex; NOS2-CD74 complex; and macrophage migration inhibitory factor receptor complex. Predicted to be active in cell surface and cytoplasm. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 7990.4), Thymus (RPKM 4614.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Cd74 in Genome Data Viewer

Location:: 18q12.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (56527071..56536406)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (54256757..54266003)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (56071420..56080851)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

macrophage migration inhibitory factor (MIF) was identified as a core regulator of inflammatory response following sciatic nerve injury through interaction with CD74 membrane receptor.
Title: MIF/CD74 axis participates in inflammatory activation of Schwann cells following sciatic nerve injury.
cytokine MIF was able to elicit inflammatory response of astrocytes through interaction with CD74 receptor, and activation of ERK was necessary for the intracellular signal transduction.
Title: Macrophage migration inhibitory factor activates inflammatory responses of astrocytes through interaction with CD74 receptor.
Methylglyoxal induced gene expression of CD74 in the in the diabetic retina.
Title: CD74 indicates microglial activation in experimental diabetic retinopathy and exogenous methylglyoxal mimics the response in normoglycemic retina.
Macrophage migration inhibitory factor(MIF)/CD74 interaction induces upregulation of cyclooxygenase (COX)-2 and prostaglandin E2 secretion in primary rodent microglia.
Title: Macrophage migration inhibitory factor activates cyclooxygenase 2-prostaglandin E2 in cultured spinal microglia.
Intraluminal blockade of cell-surface CD74 and glucose regulated protein 78 prevents substance P-induced bladder inflammatory changes in the rat
Title: Intraluminal blockade of cell-surface CD74 and glucose regulated protein 78 prevents substance P-induced bladder inflammatory changes in the rat.
Data indicate that intraluminal macrophage migration inhibitory factor, released from urothelial cells as a consequence of substance P treatment, interacts with urothelial cell-surface CD74.
Title: Substance P increases cell-surface expression of CD74 (receptor for macrophage migration inhibitory factor): in vivo biotinylation of urothelial cell-surface proteins.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CD4 receptor binding	IEA Inferred from Electronic Annotation more info
enables CD4 receptor binding	ISO Inferred from Sequence Orthology more info
enables MHC class II protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables MHC class II protein binding	ISO Inferred from Sequence Orthology more info
enables MHC class II protein binding, via antigen binding groove	IEA Inferred from Electronic Annotation more info
enables MHC class II protein binding, via antigen binding groove	ISO Inferred from Sequence Orthology more info
enables MHC class II protein complex binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
contributes_to cytokine binding	ISO Inferred from Sequence Orthology more info
enables cytokine binding	ISO Inferred from Sequence Orthology more info
contributes_to cytokine binding	ISS Inferred from Sequence or Structural Similarity more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables macrophage migration inhibitory factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables macrophage migration inhibitory factor binding	IEA Inferred from Electronic Annotation more info
enables macrophage migration inhibitory factor binding	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase binding	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within antigen processing and presentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II	ISO Inferred from Sequence Orthology more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in macrophage migration inhibitory factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in macrophage migration inhibitory factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mature B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mature B cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of peptide secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptide secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendritic cell antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic cell antigen processing and presentation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of macrophage migration inhibitory factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage migration inhibitory factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type 2 immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of type 2 immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein trimerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in response to type II interferon	IEA Inferred from Electronic Annotation more info
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in signal transduction involved in regulation of gene expression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of MHC class II protein complex	ISO Inferred from Sequence Orthology more info
part_of NOS2-CD74 complex	ISO Inferred from Sequence Orthology more info
part_of NOS2-CD74 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
part_of macrophage migration inhibitory factor receptor complex	IEA Inferred from Electronic Annotation more info
part_of macrophage migration inhibitory factor receptor complex	ISO Inferred from Sequence Orthology more info
part_of macrophage migration inhibitory factor receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in vacuole	IEA Inferred from Electronic Annotation more info
located_in vacuole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: H-2 class II histocompatibility antigen gamma chain

Names: Cd74 molecule, major histocompatibility complex, class II invariant chain; MHC class II-associated invariant chain; ia antigen-associated invariant chain; ii

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013069.2 → NP_037201.1 H-2 class II histocompatibility antigen gamma chain

See identical proteins and their annotated locations for NP_037201.1

Status: VALIDATED

Source sequence(s)

BC059152, CB611598, CB696567

UniProtKB/TrEMBL

A6IXD0, Q6GT70

Related

ENSRNOP00000025354.6, ENSRNOT00000025354.9

Conserved Domains (2) summary

pfam08831
Location:120 → 185

MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain

pfam09307
Location:1 → 112

MHC2-interact; CLIP, MHC2 interacting

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

56527071..56536406

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254761.5 → XP_006254823.1 H-2 class II histocompatibility antigen gamma chain isoform X1

See identical proteins and their annotated locations for XP_006254823.1

UniProtKB/Swiss-Prot

P10247

UniProtKB/TrEMBL

A6IXD2

Related

ENSRNOP00000106590.1, ENSRNOT00000169076.1

Conserved Domains (3) summary

cd00191
Location:196 → 255

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

pfam08831
Location:120 → 185

MHCassoc_trimer; Class II MHC-associated invariant chain trimerisation domain

pfam09307
Location:1 → 113

MHC2-interact; CLIP, MHC2 interacting