Syne4 spectrin repeat containing nuclear envelope family member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Syne4provided by RGD
Full Name: spectrin repeat containing nuclear envelope family member 4provided by RGD
Primary source: RGD:1304580
See related: AllianceGenome:RGD:1304580
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: KASH4; Syne4l1; RGD1304580
Summary: Predicted to be involved in establishment of epithelial cell apical/basal polarity. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear outer membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 76. Orthologous to human SYNE4 (spectrin repeat containing nuclear envelope family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 95.8), Liver (RPKM 36.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (94696866..94701230)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (85569409..85573775)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (88772729..88777044)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in establishment of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info
involved_in establishment of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of epithelial cell apical/basal polarity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of meiotic nuclear membrane microtubule tethering complex	IEA Inferred from Electronic Annotation more info
is_active_in nuclear outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear outer membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nesprin-4

Names: KASH domain-containing protein 4; KASH domain-containing protein C19orf46 homolog; nuclear envelope spectrin repeat protein 4; spectrin repeat containing, nuclear envelope family member 4-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.