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    Lcmt1 leucine carboxyl methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361643, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lcmt1provided by RGD
    Official Full Name
    leucine carboxyl methyltransferase 1provided by RGD
    Primary source
    RGD:735118
    See related
    EnsemblRapid:ENSRNOG00000014565 AllianceGenome:RGD:735118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein C-terminal leucine carboxyl O-methyltransferase activity. Predicted to be involved in regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to act upstream of or within several processes, including C-terminal protein methylation; negative regulation of protein-containing complex assembly; and regulation of glucose metabolic process. Predicted to be active in cytosol. Orthologous to human LCMT1 (leucine carboxyl methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 171.4), Brain (RPKM 163.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Lcmt1 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (187335173..187391195)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (177904119..177960111)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (193335629..193391620)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 11 Neighboring gene Rho GTPase activating protein 17 Neighboring gene uncharacterized LOC134483809 Neighboring gene aquaporin 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    leucine carboxyl methyltransferase 1
    Names
    [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
    NP_955437.2
    XP_006230253.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199405.3NP_955437.2  leucine carboxyl methyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q6P4Z6
      UniProtKB/TrEMBL
      A6I901
      Conserved Domains (1) summary
      pfam04072
      Location:24215
      LCM; Leucine carboxyl methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      187335173..187391195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230191.5XP_006230253.1  leucine carboxyl methyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6V3
      Related
      ENSRNOP00000087959.1, ENSRNOT00000116935.2
      Conserved Domains (1) summary
      pfam04072
      Location:24215
      LCM; Leucine carboxyl methyltransferase