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    Fads1 fatty acid desaturase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84575, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fads1provided by RGD
    Official Full Name
    fatty acid desaturase 1provided by RGD
    Primary source
    RGD:621678
    See related
    EnsemblRapid:ENSRNOG00000020480 AllianceGenome:RGD:621678
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables acyl-CoA delta5-desaturase activity. Involved in several processes, including response to insulin; response to vitamin A; and unsaturated fatty acid metabolic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrion. Biomarker of congestive heart failure; hypertension; and obesity. Orthologous to human FADS1 (fatty acid desaturase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1280.8), Adrenal (RPKM 1205.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fads1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216252605..216267618)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (206827724..206842734)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226234034..226249118)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene fatty acid desaturase 2 Neighboring gene uncharacterized LOC134483970 Neighboring gene S-formylglutathione hydrolase-like Neighboring gene transmembrane protein 258 Neighboring gene flap structure-specific endonuclease 1 Neighboring gene myelin regulatory factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Psychosocial stress, catecholamines, and essential fatty acid metabolism in rats. Mills DE, et al. Proc Soc Exp Biol Med, 1994 Jan. PMID 8115350
    2. Delta 5 desaturase activity in rat kidney microsomes. Irazú CE, et al. Mol Cell Biochem, 1993 Dec 8. PMID 8177224
    3. Effect of simvastatin on desaturase activities in liver from lean and obese Zucker rats. Georges B, et al. Lipids, 1993 Jan. PMID 8446010
    4. Age-related changes in delta 6 and delta 5 desaturase activities in rat liver microsomes. Maniongui C, et al. Lipids, 1993 Apr. PMID 8487621
    5. Fatty acid delta(5)-desaturase mRNA is regulated by dietary vitamin A and exogenous retinoic acid in liver of adult rats. Zolfaghari R, et al. Arch Biochem Biophys, 2001 Jul 1. PMID 11414679

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that an imbalance of maternal micronutrients increases Delta5 desaturase activity but decreases mRNA levels, decreases Delta6 desaturase activity but not mRNA levels as compared to control.
      Title: Effect of maternal micronutrients (folic acid, vitamin B12) and omega 3 fatty acids on liver fatty acid desaturases and transport proteins in Wistar rats.
    2. Regulation of 5-desaturase expression is different in female vs. male liver (but not cerebral cortex) during n-3 fatty acid repletion.
      Title: Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion.
    3. support a significant role for reverse Delta5-desaturase as a natural antisense regulator of Delta5-desaturase
      Title: A newly discovered member of the fatty acid desaturase gene family: a non-coding, antisense RNA gene to delta5-desaturase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acyl-CoA delta5-desaturase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyl-CoA delta5-desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA delta5-desaturase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables linoleoyl-CoA desaturase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to insulin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to isolation stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to sucrose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to vitamin A IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in unsaturated fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within unsaturated fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA (8-3)-desaturase
    Names
    D5D
    delta(5) desaturase
    delta(5) fatty acid desaturase
    NP_445897.2
    XP_006231137.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053445.2 → NP_445897.2  acyl-CoA (8-3)-desaturase

      See identical proteins and their annotated locations for NP_445897.2

      Status: PROVISIONAL

      Source sequence(s)
      AB052085
      UniProtKB/Swiss-Prot
      Q920R3, Q9EPV4
      UniProtKB/TrEMBL
      A6I010, H2BF30
      Related
      ENSRNOP00000027834.4, ENSRNOT00000027834.6
      Conserved Domains (2) summary
      PLN03198
      Location:13 → 435
      PLN03198; delta6-acyl-lipid desaturase; Provisional
      cd03506
      Location:165 → 415
      Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      216252605..216267618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231075.5 → XP_006231137.1  acyl-CoA (8-3)-desaturase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYM0, H2BF30
      Related
      ENSRNOP00000083085.1, ENSRNOT00000112242.2
      Conserved Domains (3) summary
      PLN03199
      Location:12 → 466
      PLN03199; delta6-acyl-lipid desaturase-like protein; Provisional
      cd03506
      Location:189 → 439
      Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...
      pfam00173
      Location:21 → 96
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920R3.1 GenPept UniProtKB/Swiss-Prot:Q920R3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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