Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Entpd1provided by RGD
Full Name: ectonucleoside triphosphate diphosphohydrolase 1provided by RGD
Primary source: RGD:69265
See related: EnsemblRapid:ENSRNOG00000014574 AllianceGenome:RGD:69265
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ATP-DPH; NTPDase-1
Summary: Enables ADP phosphatase activity; ATP hydrolysis activity; and identical protein binding activity. Involved in several processes, including cellular response to aluminum ion; cellular response to cytokine stimulus; and negative regulation of dopamine secretion. Located in several cellular components, including basolateral plasma membrane; synaptic membrane; and synaptic vesicle. Biomarker of demyelinating disease; hypothyroidism; intrahepatic cholestasis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 64. Orthologous to human ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 280.7), Uterus (RPKM 212.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (249374810..249502310)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (239425515..239552323)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (259692020..259818922)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PiggyBac transposon system proved to be a fast and efficient method to generate cells stably expressing SolCD39, producing high amounts of the enzyme from a limited number of cells and with high hydrolytic activity.
Title: Characterization of soluble CD39 (SolCD39/NTPDase1) from PiggyBac nonviral system as a tool to control the nucleotides level.
Studied effect of exercise on memory and cerebral cortex physiology of NTPDase-1 (CD39), 5' nucleotidase ecto (CD73), and adenosine A2a receptor (A2ar).
Title: Physical exercise prevents memory impairment in an animal model of hypertension through modulation of CD39 and CD73 activities and A2A receptor expression.
E-NTPDase activity in hepatic lymphocytes differs from its activity profile in peripheral lymphocytes.
Title: Characterization of E-NTPDase (EC 3.6.1.5) activity in hepatic lymphocytes: A different activity profile from peripheral lymphocytes.
E-NTPDase and E-ADA activities in rats experimental infected by Cryptococcus neoformans are involved in the pathogenesis of cryptococcosis.
Title: E-NTPDase and E-ADA activities in rats experimental infected by Cryptococcus neoformans.
two ENTPD isoforms, ENTPD-1 and -2, are expressed in adult rat ventricular CFs
Title: Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts.
NTPDase activity is increased in lymphocytes during experimental sepsis
Title: Increased NTPDase activity in lymphocytes during experimental sepsis.
These data suggest that NTPDase activity is altered on the surface of lymphocytes of rats infected with T. evansi at different time-points of infection.
Title: NTPDase activity in lymphocytes of rats infected by Trypanosoma evansi.
An interdomain rotation angle of up to 7.4 degrees affects the active site cleft between the two lobes of the protein.
Title: Crystallographic evidence for a domain motion in rat nucleoside triphosphate diphosphohydrolase (NTPDase) 1.
NTPDase activity can act as purinergic and cholinergic markers in lymphocytes
Title: In vitro and in vivo interactions of aluminum on NTPDase and AChE activities in lymphocytes of rats.
A significant increase in NTPDase activity was observed in lymphocytes (about 30% in ATP hydrolysis and 80% in ADP hydrolysis, at p<0.05 and p<0.01, respectively).
Title: Enzymes that hydrolyze adenine nucleotides in lymphocytes and platelets of immunosuppressed rats.

Submit: New GeneRIF Correction See all GeneRIFs (28)

General gene information

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Markers

RH124743 (e-PCR)
- UniSTS:161565

RH132060 (e-PCR)
- UniSTS:215343

AI454780 (e-PCR)
- UniSTS:246329

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ADP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables CDP phosphatase activity	IEA Inferred from Electronic Annotation more info
enables CTPase activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables GDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables IDP phosphatase activity	IEA Inferred from Electronic Annotation more info
enables ITPase activity	IEA Inferred from Electronic Annotation more info
enables UDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables apyrase activity	IEA Inferred from Electronic Annotation more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside diphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribonucleoside triphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside triphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribonucleoside triphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside triphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ADP catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to aluminum ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interferon-alpha	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleoside diphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within platelet activation	ISO Inferred from Sequence Orthology more info
involved_in platelet aggregation	IEA Inferred from Electronic Annotation more info
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in platelet aggregation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within purine ribonucleoside diphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to ATP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to L-arginine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to auditory stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to caffeine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gamma radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to proline	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ectonucleoside triphosphate diphosphohydrolase 1

Names: ATP diphosphohydrolase; ATPDase; NTPDase 1; NTPDase1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ecto-ATPase 1; ecto-apyrase; lymphoid cell activation antigen; nucleoside triphosphate diphosphohydrolase 1

NP_072109.2

EC 3.6.1.5

XP_017445154.3

EC 3.6.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.