Cnksr3 Cnksr family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cnksr3provided by RGD
Official Full Name: Cnksr family member 3provided by RGD
Primary source: RGD:1307544
See related: EnsemblRapid:ENSRNOG00000018052 AllianceGenome:RGD:1307544
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Prp4; Magi1
Summary: Predicted to be involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of peptidyl-serine phosphorylation; and positive regulation of sodium ion transport. Predicted to act upstream of or within positive regulation of sodium ion transmembrane transporter activity. Predicted to be located in apical plasma membrane and cytoplasm. Orthologous to human CNKSR3 (CNKSR family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 49.0), Kidney (RPKM 44.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (45904581..45996921, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (43499273..43591630, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (43789797..43884267, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE115327 (e-PCR)
- UniSTS:248140

ha1770 (e-PCR)
- UniSTS:515462

RH134723 (e-PCR)
- UniSTS:218001

AU048431 (e-PCR)
- UniSTS:144881

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of sodium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: connector enhancer of kinase suppressor of ras 3

Names: CNK homolog protein 3; CNK3; connector enhancer of KSR 3; maguin-like protein; membrane-associated guanylate kinase-interacting protein-like 1; parturition-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012061.1 → NP_001012061.1 connector enhancer of kinase suppressor of ras 3

See identical proteins and their annotated locations for NP_001012061.1

Status: PROVISIONAL

Source sequence(s)

AY328890

UniProtKB/Swiss-Prot

Q5SGD7, Q6VPP2

UniProtKB/TrEMBL

A0A0G2JYE3, A6KIP9

Related

ENSRNOP00000106804.1, ENSRNOT00000135265.1

Conserved Domains (5) summary

cd09511
Location:4 → 72

SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily

smart00454
Location:4 → 69

SAM; Sterile alpha motif

pfam06663
Location:334 → 545

DUF1170; Protein of unknown function (DUF1170)

pfam10534
Location:80 → 171

CRIC_ras_sig; Connector enhancer of kinase suppressor of ras

cl00117
Location:221 → 305

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...