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    Mybpc2 myosin binding protein C2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292879, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mybpc2provided by RGD
    Official Full Name
    myosin binding protein C2provided by RGD
    Primary source
    RGD:1311596
    See related
    EnsemblRapid:ENSRNOG00000019627 AllianceGenome:RGD:1311596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in sarcomere organization. Predicted to be active in M band. Orthologous to human MYBPC2 (myosin binding protein C2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 10046.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mybpc2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104130642..104154101, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94994121..95017584, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100506704..100530201, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ER membrane protein complex subunit 10 Neighboring gene golgi associated RAB2 interactor 5A Neighboring gene Spi-B transcription factor Neighboring gene DNA polymerase delta 1, catalytic subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Schiaffino S, et al. Physiol Rev, 1996 Apr. PMID 8618961
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin-binding protein C, fast-type
    Names
    myosin binding protein C, fast-type

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395062.1 → NP_001381991.1  myosin-binding protein C, fast-type

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JAQ4, D3ZA38
      Related
      ENSRNOP00000062025.2, ENSRNOT00000067754.3
      Conserved Domains (8) summary
      smart00410
      Location:444 → 506
      IG_like; Immunoglobulin like
      cd00063
      Location:636 → 722
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1045 → 1134
      I-set; Immunoglobulin I-set domain
      pfam18362
      Location:210 → 243
      THB; Tri-helix bundle domain
      cd00096
      Location:257 → 259
      Ig; Ig strand A [structural motif]
      cd05748
      Location:846 → 926
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd05894
      Location:547 → 632
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      cl11960
      Location:257 → 338
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104130642..104154101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104805.2 → XP_038960733.1  myosin-binding protein C, fast-type isoform X1

      UniProtKB/TrEMBL
      A6JAQ4, D3ZA38
      Conserved Domains (8) summary
      smart00410
      Location:459 → 521
      IG_like; Immunoglobulin like
      cd00063
      Location:651 → 737
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1060 → 1149
      I-set; Immunoglobulin I-set domain
      pfam18362
      Location:225 → 258
      THB; Tri-helix bundle domain
      cd00096
      Location:272 → 274
      Ig; Ig strand A [structural motif]
      cd05748
      Location:861 → 941
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd05894
      Location:562 → 647
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      cl11960
      Location:272 → 353
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106257.1: Suppressed sequence

      Description
      NM_001106257.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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