U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Muc6 mucin 6, oligomeric mucus/gel-forming [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282586, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Muc6provided by RGD
    Official Full Name
    mucin 6, oligomeric mucus/gel-formingprovided by RGD
    Primary source
    RGD:628826
    See related
    EnsemblRapid:ENSRNOG00000056817 AllianceGenome:RGD:628826
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be active in extracellular matrix and extracellular space. Used to study gastric ulcer. Orthologous to human MUC6 (mucin 6, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 9.9), Lung (RPKM 9.9) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Muc6 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (206155826..206194384, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196726678..196764842, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214608453..214630524, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 317 Neighboring gene adaptor related protein complex 2 subunit alpha 2 Neighboring gene uncharacterized LOC120097363 Neighboring gene mucin 2, oligomeric mucus/gel-forming Neighboring gene mucin 5AC, oligomeric mucus/gel-forming

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Enhanced expression of mucin 6 glycoprotein in cholangiocarcinoma tissue from patients in Thailand as a prognostic marker for survival. Thuwajit P, et al. J Gastroenterol Hepatol, 2008 May. PMID 18410610
    2. Aberrant expression of pyloric gland-type mucin in mucin-producing bile duct carcinomas: a clear difference between the core peptide and the carbohydrate moiety. Goto M, et al. Pathol Int, 2005 Aug. PMID 15998373
    3. The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues. Bartman AE, et al. J Pathol, 1998 Dec. PMID 10209489
    4. The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis Of the primary amino acid sequence. Toribara NW, et al. J Biol Chem, 1997 Jun 27. PMID 9195947
    5. The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the mucin in pancreatic tissue of Cftr-knockout mice. Gouyer V, et al. Histochem Cell Biol, 2010 May. PMID 20309575

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effect of geranylgeranylacetone on the expression of MUC1, MUC5AC, and MUC6 in ethanol-treated rats is reported.
      Title: Gastric mucosal protection via enhancement of MUC5AC and MUC6 by geranylgeranylacetone.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mucin-6
    Names
    mucin 6, gastric

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      206155826..206194384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098009.2 → XP_038953937.1  mucin-6

      UniProtKB/TrEMBL
      D4A6I9
      Related
      ENSRNOP00000071269.3, ENSRNOT00000089110.3
      Conserved Domains (5) summary
      smart00832
      Location:1061 → 1133
      C8; This domain contains 8 conserved cysteine residues
      cl17735
      Location:364 → 408
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:873 → 1024
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:307 → 362
      TIL; Trypsin Inhibitor like cysteine rich domain
      cd19941
      Location:769 → 832
      TIL; trypsin inhibitor-like cysteine rich domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials