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    Rce1 Ras converting CAAX endopeptidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309153, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rce1provided by RGD
    Official Full Name
    Ras converting CAAX endopeptidase 1provided by RGD
    Primary source
    RGD:1309261
    See related
    EnsemblRapid:ENSRNOG00000019468 AllianceGenome:RGD:1309261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable exopeptidase activity and metalloendopeptidase activity. Predicted to be involved in CAAX-box protein processing and protein prenylation. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human RCE1 (Ras converting CAAX endopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 104.9), Thymus (RPKM 93.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rce1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211328769..211345944, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201899358..201902593, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219860826..219863933, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 5, pseudogene 10 Neighboring gene similar to human chromosome 11 open reading frame 86 Neighboring gene pyruvate carboxylase Neighboring gene leucine rich repeat and fibronectin type III domain containing 4 Neighboring gene TOP6B like initiator of meiotic double strand breaks Neighboring gene uncharacterized LOC102553046 Neighboring gene spectrin, beta, non-erythrocytic 2 Neighboring gene RNA binding motif protein 14 Neighboring gene RNA binding motif protein 4B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. Burrows JF, et al. J Biol Chem, 2009 Apr 3. PMID 19188362, Free PMC Article
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CAAX-box protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in CAAX-box protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CAAX-box protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CAAX-box protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in CAAX-box protein processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein prenylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    CAAX prenyl protease 2
    Names
    FACE-2
    RCE1 homolog, prenyl protein peptidase
    RCE1 homolog, prenyl protein protease
    farnesylated proteins-converting enzyme 2
    prenyl protein-specific endoprotease 2
    NP_001094055.1
    XP_006230850.1
    XP_006230852.1
    XP_006230853.1
    XP_008758357.1
    XP_008758358.1
    XP_038935311.1
    XP_038935325.1
    XP_038935329.1
    XP_063120382.1
    XP_063120392.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100585.1 → NP_001094055.1  CAAX prenyl protease 2

      See identical proteins and their annotated locations for NP_001094055.1

      Status: VALIDATED

      Source sequence(s)
      BC087629, BC158593
      UniProtKB/TrEMBL
      A6HYY1, Q5M955
      Related
      ENSRNOP00000110279.1, ENSRNOT00000126937.1
      Conserved Domains (1) summary
      pfam02517
      Location:164 → 267
      Abi; CAAX protease self-immunity

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      211328769..211345944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264312.1 → XP_063120382.1  CAAX prenyl protease 2 isoform X7

      UniProtKB/TrEMBL
      A0A8L2QUF4

    2. XM_039079383.2 → XP_038935311.1  CAAX prenyl protease 2 isoform X3

      Conserved Domains (1) summary
      pfam02517
      Location:136 → 213
      Abi; CAAX protease self-immunity

    3. XM_039079397.2 → XP_038935325.1  CAAX prenyl protease 2 isoform X6

    4. XM_006230791.5 → XP_006230853.1  CAAX prenyl protease 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ABC8
      Conserved Domains (2) summary
      COG1266
      Location:169 → 245
      YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
      pfam02517
      Location:164 → 243
      Abi; CAAX protease self-immunity

    5. XM_006230790.5 → XP_006230852.1  CAAX prenyl protease 2 isoform X4

      See identical proteins and their annotated locations for XP_006230852.1

      UniProtKB/Swiss-Prot
      B0BMW8
      UniProtKB/TrEMBL
      A0A8L2QUF4
      Related
      ENSRNOP00000059208.3, ENSRNOT00000066455.3
      Conserved Domains (1) summary
      pfam02517
      Location:164 → 246
      Abi; CAAX protease self-immunity

    6. XM_006230788.5 → XP_006230850.1  CAAX prenyl protease 2 isoform X1

      Related
      ENSRNOP00000090544.2, ENSRNOT00000097288.2
      Conserved Domains (1) summary
      pfam02517
      Location:164 → 241
      Abi; CAAX protease self-immunity

    7. XM_008760135.4 → XP_008758357.1  CAAX prenyl protease 2 isoform X2

      UniProtKB/TrEMBL
      G3V8J7
      Related
      ENSRNOP00000026454.4, ENSRNOT00000026454.8

    8. XM_063264322.1 → XP_063120392.1  CAAX prenyl protease 2 isoform X10

    9. XM_008760136.3 → XP_008758358.1  CAAX prenyl protease 2 isoform X9

      See identical proteins and their annotated locations for XP_008758358.1

      UniProtKB/TrEMBL
      A6HYY2
      Conserved Domains (2) summary
      COG1266
      Location:65 → 165
      YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
      pfam02517
      Location:60 → 163
      Abi; CAAX protease self-immunity

    10. XM_039079401.2 → XP_038935329.1  CAAX prenyl protease 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GIA5
      Conserved Domains (1) summary
      pfam02517
      Location:60 → 137
      Abi; CAAX protease self-immunity

    RNA

    1. XR_010053049.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BMW8.1 GenPept UniProtKB/Swiss-Prot:B0BMW8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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