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    Rbm4 RNA binding motif protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbm4provided by RGD
    Official Full Name
    RNA binding motif protein 4provided by RGD
    Primary source
    RGD:1306891
    See related
    EnsemblRapid:ENSRNOG00000050741 AllianceGenome:RGD:1306891
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity and cyclin binding activity. Predicted to be involved in several processes, including IRES-dependent translational initiation of linear mRNA; entrainment of circadian clock by photoperiod; and regulation of translation. Predicted to act upstream of or within several processes, including insulin secretion involved in cellular response to glucose stimulus; regulation of gene expression; and regulation of insulin receptor signaling pathway. Predicted to be located in several cellular components, including cytoplasmic stress granule; nuclear lumen; and perinuclear region of cytoplasm. Orthologous to human RBM4 (RNA binding motif protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 233.6), Spleen (RPKM 184.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbm4 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211507845..211516907, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202078442..202087506, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220038403..220049756, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553046 Neighboring gene spectrin, beta, non-erythrocytic 2 Neighboring gene RNA binding motif protein 14 Neighboring gene RNA binding motif protein 4B Neighboring gene proteasome subunit alpha type-3-like Neighboring gene copper chaperone for superoxide dismutase Neighboring gene coiled-coil domain containing 87

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lark is the splicing factor RBM4 and exhibits unique subnuclear localization properties. Markus MA, et al. DNA Cell Biol, 2006 Aug. PMID 16907643
    2. RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion. Kar A, et al. J Biol Chem, 2006 Aug 25. PMID 16777844, Free PMC Article
    3. Cell stress modulates the function of splicing regulatory protein RBM4 in translation control. Lin JC, et al. Proc Natl Acad Sci U S A, 2007 Feb 13. PMID 17284590, Free PMC Article
    4. WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo. Markus MA, et al. Exp Cell Res, 2006 Oct 15. PMID 16934801
    5. RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing. Lin JC, et al. J Cell Biol, 2011 May 2. PMID 21518792, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pre-mRNA intronic binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pre-mRNA intronic pyrimidine-rich binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRES-dependent translational initiation of linear mRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cap-independent translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within enteroendocrine cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA-mediated gene silencing by inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation in response to stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pancreas development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to arsenic-containing substance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA binding motif protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170484.1 → NP_001163955.1  RNA binding motif protein 4

      See identical proteins and their annotated locations for NP_001163955.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HYZ0
      Related
      ENSRNOP00000064114.3, ENSRNOT00000071020.4
      Conserved Domains (4) summary
      PTZ00368
      Location:145 → 181
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      smart00343
      Location:161 → 176
      ZnF_C2HC; zinc finger
      cd12606
      Location:2 → 68
      RRM1_RBM4; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 4 (RBM4)
      cd12607
      Location:78 → 144
      RRM2_RBM4; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 4 (RBM4)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      211507845..211516907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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