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    Drc3 dynein regulatory complex subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287371, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Drc3provided by RGD
    Official Full Name
    dynein regulatory complex subunit 3provided by RGD
    Primary source
    RGD:1309150
    See related
    EnsemblRapid:ENSRNOG00000021303 AllianceGenome:RGD:1309150
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lrrc48; RGD1309150
    Summary
    Predicted to be located in axoneme and sperm flagellum. Predicted to be active in cilium. Orthologous to human DRC3 (dynein regulatory complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 39.3), Testes (RPKM 36.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Drc3 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45620045..45698902)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45149094..45200659)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46712021..46762276)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549418 Neighboring gene retinoic acid induced 1 Neighboring gene sterol regulatory element binding transcription factor 1 Neighboring gene target of myb1 like 2 membrane trafficking protein Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene ribosomal protein S4, X-linked, pseudogene 6 Neighboring gene GID complex subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex. Olbrich H, et al. Am J Hum Genet, 2015 Oct 1. PMID 26387594, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dynein regulatory complex subunit 3
    Names
    leucine rich repeat containing 48
    leucine-rich repeat-containing protein 48

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013857.1 → NP_001013879.1  dynein regulatory complex subunit 3

      See identical proteins and their annotated locations for NP_001013879.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083838
      UniProtKB/Swiss-Prot
      Q5XI54
      Conserved Domains (3) summary
      sd00031
      Location:48 → 66
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:65 → 105
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:66 → 121
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      45620045..45698902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268617.1 → XP_063124687.1  dynein regulatory complex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI54

    2. XM_063268614.1 → XP_063124684.1  dynein regulatory complex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI54

    3. XM_063268618.1 → XP_063124688.1  dynein regulatory complex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI54

    4. XM_063268619.1 → XP_063124689.1  dynein regulatory complex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI54

    5. XM_063268615.1 → XP_063124685.1  dynein regulatory complex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI54
      Related
      ENSRNOP00000111553.1, ENSRNOT00000158365.1

    6. XM_063268621.1 → XP_063124691.1  dynein regulatory complex subunit 3 isoform X3

    7. XM_063268622.1 → XP_063124692.1  dynein regulatory complex subunit 3 isoform X4

    8. XM_063268620.1 → XP_063124690.1  dynein regulatory complex subunit 3 isoform X2

      Related
      ENSRNOP00000038778.5, ENSRNOT00000032685.6

    9. XM_063268613.1 → XP_063124683.1  dynein regulatory complex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI54
      Related
      ENSRNOP00000100747.1, ENSRNOT00000151269.1

    10. XM_063268616.1 → XP_063124686.1  dynein regulatory complex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI54
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI54.1 GenPept UniProtKB/Swiss-Prot:Q5XI54

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