Alox12b arachidonate 12-lipoxygenase, 12R type [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alox12bprovided by RGD
Official Full Name: arachidonate 12-lipoxygenase, 12R typeprovided by RGD
Primary source: RGD:1305330
See related: EnsemblRapid:ENSRNOG00000022210 AllianceGenome:RGD:1305330
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable arachidonate 12(S)-lipoxygenase activity; arachidonate 8(R)-lipoxygenase activity; and linoleate 9S-lipoxygenase activity. Involved in arachidonate metabolic process and hepoxilin biosynthetic process. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 2. Orthologous to human ALOX12B (arachidonate 12-lipoxygenase, 12R type). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 22.5) and Testes (RPKM 3.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54361898..54373776)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (53863060..53874938)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (55744646..55756524)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In summary, our data indicate that vitamin K prevents oxidative cell death by blocking activation of 12-LOX and ROS generation.
Title: Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonate 12(R)-lipoxygenase activity	IEA Inferred from Electronic Annotation more info
enables arachidonate 12(S)-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate 12(S)-lipoxygenase activity	IEA Inferred from Electronic Annotation more info
enables arachidonate 12(S)-lipoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate 12(S)-lipoxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables arachidonate 8(R)-lipoxygenase activity	IEA Inferred from Electronic Annotation more info
enables arachidonate 8(R)-lipoxygenase activity	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables linoleate 9S-lipoxygenase activity	IEA Inferred from Electronic Annotation more info
enables linoleate 9S-lipoxygenase activity	ISO Inferred from Sequence Orthology more info
enables linoleate 9S-lipoxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in arachidonate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
NOT involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in ceramide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ceramide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of skin barrier	IEA Inferred from Electronic Annotation more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in hepoxilin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hepoxilin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in linoleic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in linoleic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in linoleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in linoleic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid oxidation	IEA Inferred from Electronic Annotation more info
involved_in lipoxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoxygenase pathway	IEA Inferred from Electronic Annotation more info
involved_in lipoxygenase pathway	ISO Inferred from Sequence Orthology more info
involved_in lipoxygenase pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mucus secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mucus secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein lipidation	ISO Inferred from Sequence Orthology more info
involved_in protein lipidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in sphingolipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arachidonate 12-lipoxygenase, 12R-type

Names: 12R-LOX; 12R-lipoxygenase; epidermis-type lipoxygenase 12

NP_001034466.1

EC 1.13.11.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039377.1 → NP_001034466.1 arachidonate 12-lipoxygenase, 12R-type

See identical proteins and their annotated locations for NP_001034466.1

Status: PROVISIONAL

Source sequence(s)

AY903231

UniProtKB/Swiss-Prot

Q2KMM4, Q2KMM5

UniProtKB/TrEMBL

A0A140TAE7

Related

ENSRNOP00000033009.5, ENSRNOT00000039535.8

Conserved Domains (2) summary

cd01753
Location:2 → 116

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

pfam00305
Location:163 → 681

Lipoxygenase; Lipoxygenase