Mgrn1 mahogunin ring finger 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mgrn1provided by RGD
Official Full Name: mahogunin ring finger 1provided by RGD
Primary source: RGD:1311862
See related: EnsemblRapid:ENSRNOG00000003234 AllianceGenome:RGD:1311862
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311862
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in endosome to lysosome transport; negative regulation of signal transduction; and protein monoubiquitination. Predicted to act upstream of or within several processes, including heart development; protein polyubiquitination; and smoothened signaling pathway. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in early endosome and nucleus. Orthologous to human MGRN1 (mahogunin ring finger 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 284.9), Brain (RPKM 186.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (11142626..11194773, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (10638881..10688332, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (10832573..10881999, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

With aging, the neuroprotective e3 ligase MGRN1 relocates from the cytosol to the nucleus of neurons, where it associates with chromatin and potentiates the cellular response to proteotoxic stress. This nuclear shift is due to a proteasome impairment dependent increase of a monoubiquitinated form of MGRN1.
Title: Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mco27 (e-PCR)
- UniSTS:240204

RH144481 (e-PCR)
- UniSTS:233726

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport	IEA Inferred from Electronic Annotation more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase MGRN1

Names: RING-type E3 ubiquitin transferase MGRN1; mahoganoid; mahogunin RING finger protein 1; mahogunin ring finger 1, E3 ubiquitin protein ligase; probable E3 ubiquitin-protein ligase MGRN1

NP_001013986.1

EC 2.3.2.27

XP_006245854.1

EC 2.3.2.27

XP_006245855.1

EC 2.3.2.27

XP_006245856.1

EC 2.3.2.27

XP_006245857.1

EC 2.3.2.27

XP_006245858.1

EC 2.3.2.27

XP_008765707.1

EC 2.3.2.27

XP_008765708.1

EC 2.3.2.27

XP_017452702.1

EC 2.3.2.27

XP_038941772.1

EC 2.3.2.27

XP_038941773.1

EC 2.3.2.27

XP_063124968.1

EC 2.3.2.27

XP_063124969.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013964.1 → NP_001013986.1 E3 ubiquitin-protein ligase MGRN1

See identical proteins and their annotated locations for NP_001013986.1

Status: PROVISIONAL

Source sequence(s)

BC083621

UniProtKB/Swiss-Prot

Q5XIQ4

UniProtKB/TrEMBL

A0A8I6AKW4

Conserved Domains (3) summary

PHA02929
Location:233 → 332

PHA02929; N1R/p28-like protein; Provisional

TIGR00599
Location:274 → 494

rad18; DNA repair protein rad18

pfam13920
Location:278 → 320

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

11142626..11194773 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245795.4 → XP_006245857.1 E3 ubiquitin-protein ligase MGRN1 isoform X4

UniProtKB/TrEMBL

A0A8I6GKG5

Related

ENSRNOP00000004416.7, ENSRNOT00000004416.8

Conserved Domains (3) summary

PHA02929
Location:232 → 331

PHA02929; N1R/p28-like protein; Provisional

TIGR00599
Location:273 → 493

rad18; DNA repair protein rad18

pfam13920
Location:274 → 319

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
XM_006245793.5 → XP_006245855.1 E3 ubiquitin-protein ligase MGRN1 isoform X2

UniProtKB/TrEMBL

A0A8I5Y9P4, A0A8I6AKW4

Related

ENSRNOP00000077703.1, ENSRNOT00000117920.2

Conserved Domains (3) summary

PHA02929
Location:232 → 331

PHA02929; N1R/p28-like protein; Provisional

TIGR00599
Location:273 → 515

rad18; DNA repair protein rad18

pfam13920
Location:277 → 319

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
XM_006245794.5 → XP_006245856.1 E3 ubiquitin-protein ligase MGRN1 isoform X3

UniProtKB/TrEMBL

A0A8I6GKG5

Conserved Domains (3) summary

PHA02929
Location:233 → 332

PHA02929; N1R/p28-like protein; Provisional

TIGR00599
Location:274 → 494

rad18; DNA repair protein rad18

pfam13920
Location:275 → 320

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
XM_006245792.5 → XP_006245854.1 E3 ubiquitin-protein ligase MGRN1 isoform X1

UniProtKB/TrEMBL

A0A8I6AKW4

Conserved Domains (3) summary

PHA02929
Location:233 → 332

PHA02929; N1R/p28-like protein; Provisional

TIGR00599
Location:274 → 516

rad18; DNA repair protein rad18

pfam13920
Location:278 → 320

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
XM_017597213.3 → XP_017452702.1 E3 ubiquitin-protein ligase MGRN1 isoform X7

UniProtKB/TrEMBL

A0A8I6AKW4
XM_039085845.2 → XP_038941773.1 E3 ubiquitin-protein ligase MGRN1 isoform X11

Conserved Domains (2) summary

cd16789
Location:53 → 93

mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins

cl29320
Location:8 → 107

KilA-N; KilA-N domain
XM_063268899.1 → XP_063124969.1 E3 ubiquitin-protein ligase MGRN1 isoform X12
XM_008767486.3 → XP_008765708.1 E3 ubiquitin-protein ligase MGRN1 isoform X8

See identical proteins and their annotated locations for XP_008765708.1

UniProtKB/TrEMBL

A0A8I6AKW4, A0A8L2Q0V6, G3C8Z1

Conserved Domains (3) summary

PHA02929
Location:232 → 331

PHA02929; N1R/p28-like protein; Provisional

TIGR00599
Location:273 → 493

rad18; DNA repair protein rad18

pfam13920
Location:277 → 319

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
XM_008767485.3 → XP_008765707.1 E3 ubiquitin-protein ligase MGRN1 isoform X6

See identical proteins and their annotated locations for XP_008765707.1

UniProtKB/TrEMBL

A0A8I6AKW4, D3ZEH9

Related

ENSRNOP00000095969.2, ENSRNOT00000095237.2

Conserved Domains (3) summary

PHA02929
Location:232 → 331

PHA02929; N1R/p28-like protein; Provisional

TIGR00599
Location:273 → 515

rad18; DNA repair protein rad18

pfam13920
Location:277 → 319

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
XM_006245796.5 → XP_006245858.1 E3 ubiquitin-protein ligase MGRN1 isoform X5

UniProtKB/TrEMBL

A0A8I6AKW4

Conserved Domains (3) summary

PHA02929
Location:233 → 332

PHA02929; N1R/p28-like protein; Provisional

TIGR00599
Location:274 → 516

rad18; DNA repair protein rad18

pfam13920
Location:278 → 320

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
XM_063268898.1 → XP_063124968.1 E3 ubiquitin-protein ligase MGRN1 isoform X10
XM_039085844.2 → XP_038941772.1 E3 ubiquitin-protein ligase MGRN1 isoform X9

Conserved Domains (2) summary

cd16789
Location:278 → 318

mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins

cl29320
Location:233 → 332

KilA-N; KilA-N domain